Tang M M, Thevarajah S
Hospital Kuala Lumpur, Dermatology, Department of Dermatology, Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Wilayah Persekutuan 50586, Malaysia.
Med J Malaysia. 2010 Jun;65(2):138-42.
Adult-onset dermatomyositis has been found to be associated with underlying malignancies in up to 40% of patients. The aims of this study were to determine the demographic profile, the underlying cancer and outcome in patients with dermatomyositis. This was a retrospective review of 38 patients with dermatomyositis seen over a 12-year period in the Department of Dermatology, Kuala Lumpur Hospital. Of these, 18 (47.4%) had an associated underlying malignancy. The male to female ratio was 2:1. Ten patients (55.6%) were Chinese. The youngest patient encountered was 32 years old. Nasopharyngeal carcinoma (61.1%) was the most common malignancy in our study population. Tumour markers were not useful as the initial screening for malignancies. Thorough screening for malignancy is imperative in adult dermatomyositis especially those above 40 years old.
成人起病的皮肌炎被发现高达40%的患者与潜在恶性肿瘤有关。本研究的目的是确定皮肌炎患者的人口统计学特征、潜在癌症及预后。这是一项对吉隆坡医院皮肤科12年间诊治的38例皮肌炎患者的回顾性研究。其中18例（47.4%）有相关的潜在恶性肿瘤。男女比例为2:1。10例患者（55.6%）为华裔。最年轻的患者为32岁。鼻咽癌（61.1%）是我们研究人群中最常见的恶性肿瘤。肿瘤标志物对恶性肿瘤的初始筛查无用。对成人皮肌炎患者，尤其是40岁以上患者，必须进行全面的恶性肿瘤筛查。
