Irekeola Ahmad Adebayo, Shueb Rafidah Hanim, E A R Engku Nur Syafirah, Wada Yusuf, Abdul Rahman Zaidah, Ahmad Suhana, Mohamud Rohimah, Mat Lazim Norhafiza, Yean Chan Yean
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Microbiology Unit, Department of Biological Sciences, College of Natural and Applied Sciences, Summit University Offa, Offa PMB 4412, Nigeria.
Cancers (Basel). 2021 Apr 14;13(8):1886. doi: 10.3390/cancers13081886.
For more than 50 years, nasopharyngeal carcinoma (NPC) has been associated with dermatomyositis (DM), a rare idiopathic inflammatory disorder that mainly affects the skin and muscles. Although the association between these rare diseases is well-documented, the actual prevalence of NPC in DM patients remains unknown. Here, a systematic review and meta-analysis of published data was conducted in accordance with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar were searched without year or language restrictions for studies reporting the occurrence of NPC in DM patients. The study protocol was lodged with PROSPERO (CRD42021225335). A total of 95 studies covering 303 cases of NPC among 16,010 DM patients was included. Summary estimates were calculated using the random-effects model. The pooled prevalence of NPC in DM was 3.3% (95% CI, 2.5-4.3). When stratified according to study location, higher prevalence estimates were obtained for Hong Kong (36.5%), Malaysia (27.7%), and Singapore (11.9%). There was a predominance of cases among male DM patients compared with females, and most patients were aged 40 and above. Many of the NPC cases were found to be diagnosed after the diagnosis of DM. It is therefore pertinent to screen for NPC in DM patients, especially among older DM patients in the Asian region.
五十多年来，鼻咽癌（NPC）一直与皮肌炎（DM）相关，皮肌炎是一种罕见的特发性炎症性疾病，主要影响皮肤和肌肉。尽管这些罕见疾病之间的关联已有充分记录，但DM患者中NPC的实际患病率仍然未知。在此，根据系统评价和Meta分析的首选报告项目（PRISMA）指南，对已发表的数据进行了系统评价和Meta分析。对包括PubMed、Scopus、ScienceDirect和谷歌学术在内的电子数据库进行了检索，检索时不受年份或语言限制，以查找报告DM患者中NPC发生情况的研究。该研究方案已提交给国际前瞻性系统评价注册库（PROSPERO，注册号：CRD42021225335）。共纳入95项研究，涉及16010例DM患者中的303例NPC病例。使用随机效应模型计算汇总估计值。DM患者中NPC的合并患病率为3.3%（95%CI，2.5-4.3）。按研究地点分层时，香港（36.5%）、马来西亚（27.7%）和新加坡（11.9%）的患病率估计值较高。与女性DM患者相比，男性DM患者中的病例占主导地位，且大多数患者年龄在40岁及以上。许多NPC病例是在DM诊断后被发现的。因此，对DM患者，尤其是亚洲地区老年DM患者进行NPC筛查是很有必要的。
