Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2021 Jan;42(1):100-104. doi: 10.15537/smj.2021.1.25590.
To describes the epidemiology of cancer in patients with idiopathic inflammatory myopathies (IIM) treated at 2 tertiary centers in Riyadh, Saudi Arabia.
This was a retrospective multi-center study evaluating the prevalence and the type of malignancy in an IIM population in King Saud University Medical City and King Abdulaziz Medical City between August 2017 to August 2018.
In total, 60 patients were included. Four had neoplasms (6.7%), 2 men had lymphoma, a woman had breast cancer and a second, ovarian cancer. Two patients died due to cancer or its complications. Older age (age greater than 40 years), dysphagia, necrotic rash, absence of interstitial lung disease, high erythrocyte sedimentation rate and a negative anti Jo-1 antibody were potentially predictive risk factors for neoplasm. All patients diagnosed with cancer-associated myositis were investigated with routine and invasive modalities. Three of the 4 patients had abnormal findings in both modalities. One patient, the routine investigations were unremarkable, but a computed tomography of the pelvis revealed an ovarian mass that was subsequently diagnosed as malignant. Conclusion: An individualized approach might be more appropriate for high risk patients. Larger prospective studies are required to confirm the findings of the current study.
描述在沙特阿拉伯利雅得的 2 家三级中心治疗的特发性炎症性肌病（IIM）患者的癌症流行病学。
这是一项回顾性多中心研究，评估了 2017 年 8 月至 2018 年 8 月在 King Saud University Medical City 和 King Abdulaziz Medical City 的 IIM 人群中的恶性肿瘤患病率和类型。
共有 60 例患者纳入研究。4 例有肿瘤（6.7%），2 例为男性淋巴瘤，1 例为乳腺癌，另 1 例为卵巢癌。2 例患者因癌症或其并发症死亡。年龄较大（年龄大于 40 岁）、吞咽困难、坏死性皮疹、无间质性肺病、红细胞沉降率高和抗 Jo-1 抗体阴性可能是肿瘤的潜在预测危险因素。所有诊断为癌症相关肌炎的患者均接受了常规和侵入性检查。4 例患者中有 3 例两种检查均有异常。1 例患者常规检查无异常，但骨盆 CT 显示卵巢肿块，随后诊断为恶性。结论：对于高危患者，个体化方法可能更为合适。需要更大的前瞻性研究来证实本研究的结果。
