Saito K, Shimojo N, Hoshioka A, Kohno Y, Niimi H, Nakajima H, Tanabe E, Koyama A
Department of Pediatrics, School of Medicine, Chiba University.
Arerugi. 1990 Mar;39(3):348-53.
Systemic lupus erythematosus (SLE) is a disease caused by immune complexes (IC) and is sometimes accompanied by cutaneous vasculitis at the time of onset or in case of relapse. Usually, however, this manifestation does not newly develop after the beginning of steroid treatment. Here we report on a 16-year-old boy with SLE who developed cutaneous vasculitis 10 days after starting systemic prednisolone treatment despite improvements in clinical and laboratory parameters. We examined the molecular sizes of circulating immune complexes (CIC) through the course of the disease. At the time of admission the CIC were 7S to 19S in size. When the patient developed cutaneous vasculitis, the large component of CIC decreased and the 7S CIC became the major component. Although definitive conclusions cannot be drawn, it is suggested that the shift to the smaller size of the CIC is related to the development of cutaneous vasculitis.
系统性红斑狼疮（SLE）是一种由免疫复合物（IC）引起的疾病，在发病时或复发时有时会伴有皮肤血管炎。然而，通常情况下，这种表现不会在开始使用类固醇治疗后新出现。在此，我们报告一名16岁的SLE男孩，尽管临床和实验室指标有所改善，但在开始全身使用泼尼松龙治疗10天后出现了皮肤血管炎。我们在疾病过程中检测了循环免疫复合物（CIC）的分子大小。入院时CIC的大小为7S至19S。当患者出现皮肤血管炎时，CIC的大分子成分减少，7S CIC成为主要成分。尽管无法得出明确结论，但提示CIC向较小尺寸的转变与皮肤血管炎的发生有关。
