系统性红斑狼疮患者中C3d固定循环免疫复合物与疾病活动度及临床参数的相关性
Correlation of C3d fixing circulating immune complexes with disease activity and clinical parameters in patients with systemic lupus erythematosus.
作者信息
Sekita K, Doi T, Muso E, Yoshida H, Kanatsu K, Hamashima Y
出版信息
Clin Exp Immunol. 1984 Mar;55(3):487-94.
Using anti-C3d as a solid phase reagent, C3d fixing circulating immune complexes (CIC) were detected in sera from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, membranous nephropathy and IgA nephropathy. Particularly, sera from SLE showed the highest CIC levels and highest incidence of positivity among these diseases. In the 51 serum samples from 48 patients with SLE we studied, the CIC detected by the anti-C3d assay correlated well (P less than 0.01) with the CIC detected by the solid phase C1q assay, but not with those detected by the conglutinin assay. In addition, the CIC detected by the anti-C3d assay correlated more significantly (P less than 0.001) with disease activity, as well as some clinical parameters (serum anti-dsDNA antibodies, CH50 and C3 levels) than CIC detected by the other two assays of SLE sera. The anti-C3d binding materials were found to be of intermediate (8-19S) and small (7S) sizes in a small number of SLE sera which we analysed.
以抗C3d作为固相试剂，在系统性红斑狼疮（SLE）、类风湿性关节炎、膜性肾病和IgA肾病患者的血清中检测到固定C3d的循环免疫复合物（CIC）。特别是，SLE患者的血清在这些疾病中显示出最高的CIC水平和最高的阳性发生率。在我们研究的48例SLE患者的51份血清样本中，抗C3d检测法检测到的CIC与固相C1q检测法检测到的CIC相关性良好（P小于0.01），但与胶固素检测法检测到的CIC不相关。此外，与其他两种SLE血清检测法检测到的CIC相比，抗C3d检测法检测到的CIC与疾病活动度以及一些临床参数（血清抗双链DNA抗体、CH50和C3水平）的相关性更显著（P小于0.001）。在我们分析的少数SLE血清中，发现抗C3d结合物质的大小为中等（8-19S）和小（7S）。
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