Raroque H G, Mandler R N, Griffey M S, Orrison W W, Kornfeld M
Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
Arch Neurol. 1990 Aug;47(8):929-30. doi: 10.1001/archneur.1990.00530080117019.
A 60-year-old white man presented with aphasia, seizures, paraparesis, and incontinence. His serologic and hematologic profiles were unremarkable. His cerebrospinal fluid showed pleocytosis, increased daily central nervous system IgG synthesis, increased myelin basic protein, and negative cytology and cultures. Cerebral computed tomography exhibited multiple areas of hypodensity but spinal computed tomography and myelography showed no abnormalities. Cranial and spinal magnetic resonance imaging revealed areas of increased signal on T2-weighted images. The use of gadolinium-pentetic acid on T1-weighted images delineated smaller areas of cortical enhancement with surrounding rim of decreased signal. Brain biopsy showed intravascular malignant cells positive for leukocyte common antigen and B-cell markers. The diagnosis was neoplastic angioendotheliomatosis (intravascular lymphomatosis). To our knowledge, this is the first report on the use of both cranial and spinal magnetic resonance imaging in this condition.
一名60岁白人男性出现失语、癫痫发作、下肢轻瘫和尿失禁症状。其血清学和血液学检查结果无异常。脑脊液显示有细胞增多、每日中枢神经系统IgG合成增加、髓鞘碱性蛋白增加，细胞学检查和培养结果均为阴性。脑部计算机断层扫描显示多个低密度区域，但脊髓计算机断层扫描和脊髓造影未显示异常。头颅和脊髓磁共振成像显示在T2加权图像上信号增强区域。在T1加权图像上使用钆喷替酸勾勒出较小的皮质强化区域，周围有信号降低的边缘。脑活检显示血管内恶性细胞白细胞共同抗原和B细胞标志物呈阳性。诊断为肿瘤性血管内皮瘤病（血管内淋巴瘤病）。据我们所知，这是关于在此病中同时使用头颅和脊髓磁共振成像的首例报告。
