Microbial Interactions and Processes Research Group, Department of Medical Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Environ Microbiol Rep. 2012 Feb;4(1):126-32. doi: 10.1111/j.1758-2229.2011.00313.x. Epub 2011 Dec 12.
The anterior nares (nostrils), are an important niche for bacterial colonization by both commensals and opportunistic pathogens. Here the temporal dynamics and variation of the global nasal bacterial community across 25 healthy volunteers was evaluated over 15 months. Overall, there was a global seasonal shift in bacterial community structure. Such a temporal shift was also strongly evident in the abundances of species such as Propionibacterium acnes and Staphylococcus epidermidis. However, such species dynamics over time was also inter-individual-dependent, and both individuals with highly stable communities and those with highly flexible communities could be defined. Even though the bacterial community of individual volunteers was thus generally variable over time and permanent carriage of a given species was seldomly observed, various species previously defined as constituting the core bacterial community could be identified as persistent in a subset of the volunteers suggesting that these same species also constitute to a 'temporal' core community.
鼻腔（鼻孔）是细菌定殖的重要部位，包括共生菌和机会致病菌。本研究旨在评估 25 名健康志愿者的鼻腔细菌群落的全球季节性动态和变异性，时间跨度为 15 个月。总的来说，细菌群落结构存在全球性的季节性转变。痤疮丙酸杆菌和表皮葡萄球菌等物种的丰度也明显存在这种时间变化。然而，随着时间的推移，这种物种动态也依赖于个体，具有高度稳定群落的个体和具有高度灵活群落的个体都可以被定义。尽管个体志愿者的细菌群落总体上随时间变化，并且很少观察到特定物种的持续携带，但先前定义为核心细菌群落的各种物种可以被鉴定为在一部分志愿者中持续存在，这表明这些相同的物种也构成了一个“时间”核心群落。
