Microbial Interactions and Processes Research Group, Department of Medical Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
ISME J. 2010 Jul;4(7):839-51. doi: 10.1038/ismej.2010.15. Epub 2010 Feb 25.
The anterior nares are the major reservoir for Staphylococcus aureus in humans, where nasal carriage has a crucial function as a source for invasive infections. Despite various investigations on aerobic community members based on traditional cultivation methods, little is known on the overall microbial composition and complex in situ interactions, but such knowledge is highly warranted for effective S. aureus control strategies. As assessed using advanced culture-independent approaches, this study provides a comprehensive survey of the anterior nare bacterial community of 40 individuals. Previously undiscovered co-colonization patterns and natural variations in species composition were revealed and provide insights for future intervention strategies for the control of health-care- and community-associated S. aureus infections.
鼻腔前部是金黄色葡萄球菌在人类体内的主要储存库，鼻腔携带在作为侵袭性感染的来源方面起着关键作用。尽管基于传统培养方法对需氧群落成员进行了各种研究，但对于整体微生物组成和复杂的原位相互作用知之甚少，但为了制定有效的金黄色葡萄球菌控制策略，这种知识是非常必要的。通过使用先进的非培养方法进行评估，本研究对 40 个人的前鼻腔细菌群落进行了全面调查。揭示了以前未发现的共同定植模式和物种组成的自然变化，并为未来控制与医疗保健和社区相关的金黄色葡萄球菌感染的干预策略提供了新的见解。
