蜂毒肽刺激肝脏糖原分解以及前列腺素D2和血栓素B2的释放。
Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2.
作者信息
García-Sáinz J A, Hernández-Sotomayor S M, Macías-Silva M
机构信息
Departamento de Bioenergética, Universidad Nacional Autónoma de México, D.F.
出版信息
Biochem J. 1990 Jul 1;269(1):273-5. doi: 10.1042/bj2690273.
Abstract
Melittin stimulates glycogenolysis and induces vasoconstriction in perfused rat liver. The effect was rapid and associated with production and release of prostaglandin D2 and thromboxane B2. Indomethacin blocked the release of these eicosanoids and the stimulation of glycogenolysis induced by melittin. Ibuprofen blocked the release of prostaglandin D2 induced by melittin and markedly attenuated that of thromboxane B2. Interestingly, the initial burst of glucose output induced by melittin was not inhibited by ibuprofen, although the duration of the glycogenolytic action of the peptide was greatly diminished.
摘要
蜂毒肽可刺激灌注大鼠肝脏中的糖原分解并诱导血管收缩。该作用迅速，且与前列腺素D2和血栓素B2的产生及释放有关。吲哚美辛可阻断这些类花生酸的释放以及蜂毒肽诱导的糖原分解。布洛芬可阻断蜂毒肽诱导的前列腺素D2的释放，并显著减弱血栓素B2的释放。有趣的是，尽管该肽的糖原分解作用持续时间大大缩短，但布洛芬并未抑制蜂毒肽诱导的葡萄糖输出的初始激增。
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