Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu, Finland.
J Clin Periodontol. 2013 Aug;40(8):765-70. doi: 10.1111/jcpe.12129. Epub 2013 Jun 12.
Besides their role in bone metabolism, receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) are also known to be associated with inflammation. We explored associations between the extent/severity of periodontitis and circulating levels of sRANKL and OPG and their ratio using a cross-sectional study design.
SUBJECTS & METHODS: The extent of periodontal inflammation and tissue destruction and the serum levels of sRANKL (pg/ml) and OPG (pg/ml) were determined in 80 subjects with type 1 diabetes mellitus (T1DM). Plaque-, age-, gender-, smoking-, HbA1c- and body mass index-adjusted associations between periodontal parameters and serum sRANKL, OPG and their ratio were studied using multiple linear regression analysis.
Adjusted regression analyses of all the subjects indicated a significant positive association between AL ≥ 4 mm and severity of periodontitis and the level of serum OPG. A major drop in the strength and statistical significance of the above association was observed when the analyses included only non-smokers. Serum sRANKL level and sRANKL/OPG ratio were not associated with periodontitis.
Our observations suggest that serum OPG may be an indicator of periodontal tissue destruction in T1DM.
核因子-κB 受体激活剂配体（RANKL）和骨保护素（OPG）除了在骨代谢中的作用外，还与炎症有关。我们通过横断面研究设计探讨了牙周炎的严重程度与循环中可溶性 RANKL 和 OPG 及其比值的关系。
在 80 例 1 型糖尿病患者（T1DM）中，确定了牙周炎的严重程度、组织破坏程度、血清可溶性 RANKL（pg/ml）和 OPG（pg/ml）水平。使用多元线性回归分析，对牙周参数与血清 sRANKL、OPG 及其比值之间的关系进行了斑块、年龄、性别、吸烟、HbA1c 和体重指数调整。
对所有受试者的调整回归分析表明，AL≥4mm 和牙周炎严重程度与血清 OPG 水平呈显著正相关。当仅包括非吸烟者进行分析时，上述相关性的强度和统计学意义明显下降。血清 sRANKL 水平和 sRANKL/OPG 比值与牙周炎无关。
我们的观察表明，血清 OPG 可能是 T1DM 牙周组织破坏的一个指标。
