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RDR6 指导的 DNA 甲基化途径引发转座元件沉默的拟议机制。

Proposed mechanism for the initiation of transposable element silencing by the RDR6-directed DNA methylation pathway.

机构信息

Department of Molecular Genetics; The Ohio State University; Columbus, OH USA.

出版信息

Plant Signal Behav. 2013 Aug;8(8). doi: 10.4161/psb.25206. Epub 2013 Jun 5.

DOI:10.4161/psb.25206
PMID:23759554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3999056/
Abstract

The activity of transposable elements is epigenetically suppressed by both transcriptional and post-transcriptional mechanisms. We recently identified a direct connection between the small RNA-mediated post-transcriptional mRNA degradation of actively transcribing transposable elements and the de novo methylation of transposable element DNA, providing a mechanistic link between these two established pathways of transposable element silencing. Here we provide a model for the initiation, establishment and epigenetic maintenance of transposable element silencing that incorporates recent data in this rapidly emerging field.

摘要

转座元件的活性受到转录和转录后机制的表观遗传抑制。我们最近发现，活跃转录的转座元件的小 RNA 介导的转录后 mRNA 降解与转座元件 DNA 的从头甲基化之间存在直接联系，为这两种已建立的转座元件沉默途径之间提供了一个机制联系。在这里，我们提供了一个转座元件沉默的起始、建立和表观遗传维持的模型，该模型整合了该快速发展领域的最新数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca84/3999056/437a8fcc9998/psb-8-e25206-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca84/3999056/437a8fcc9998/psb-8-e25206-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca84/3999056/437a8fcc9998/psb-8-e25206-g1.jpg

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