Department of Dermatology, Venerology, and Allergology, University Medical Center Göttingen, Göttingen, Germany.
J Invest Dermatol. 2013 Jul;133(7):1713-7. doi: 10.1038/jid.2013.72.
Nucleotide excision repair (NER) removes UV-induced DNA damage and other bulky DNA lesions, thereby maintaining genomic integrity. Dr Qingyi Wei's group demonstrated over the last decade that NER fidelity and single-nucleotide polymorphisms (SNPs) in NER genes constitute melanoma risk biomarkers. In this issue, Li et al. provide evidence that SNPs in NER genes may also predict melanoma survival.
核苷酸切除修复（NER）可清除 UV 诱导的 DNA 损伤和其他大型 DNA 损伤，从而维持基因组完整性。魏清义博士的研究团队在过去十年中证明，NER 保真度和 NER 基因中的单核苷酸多态性（SNPs）构成了黑色素瘤风险生物标志物。在本期中，李等人提供了证据表明，NER 基因中的 SNPs 也可能预测黑色素瘤的生存。
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