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1
Infection with feline immunodeficiency virus directly activates CD4+ CD25+ T regulatory cells.猫免疫缺陷病毒感染直接激活 CD4+ CD25+ T 调节细胞。
J Virol. 2013 Aug;87(16):9373-8. doi: 10.1128/JVI.00996-13. Epub 2013 Jun 12.
2
CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism.在猫免疫缺陷病毒感染期间被激活的 CD4+CD25+T 调节细胞通过膜结合的 TGFβ/GARP 介导的机制将辅助性 T 细胞转化为功能性抑制细胞。
Virol J. 2014 Jan 18;11:7. doi: 10.1186/1743-422X-11-7.
3
Transforming growth factor-beta/transforming growth factor-betaRII signaling may regulate CD4+CD25+ T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection.转化生长因子-β/转化生长因子-β受体II信号传导可能调节猫艾滋病慢病毒感染中CD4+CD25+调节性T细胞的稳态和抑制功能。
J Acquir Immune Defic Syndr. 2008 Feb 1;47(2):148-60. doi: 10.1097/QAI.0b013e318160df70.
4
Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells.猫免疫缺陷病毒感染在表型和功能上激活免疫抑制性CD4+CD25+调节性T细胞。
J Immunol. 2004 Apr 15;172(8):4752-61. doi: 10.4049/jimmunol.172.8.4752.
5
CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism.CD4(+)CD25(+)调节性T细胞在急性和慢性猫免疫缺陷病毒感染期间利用膜转化生长因子-β依赖性机制抑制CD8(+)干扰素-γ的产生。
AIDS Res Hum Retroviruses. 2010 Feb;26(2):201-16. doi: 10.1089/aid.2009.0162.
6
Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency.猫科动物富含糖蛋白A重复序列的锚定蛋白将转化生长因子β固定在活化的CD4(+)CD25(+)调节性T细胞表面，并介导艾滋病慢病毒诱导的T细胞免疫缺陷。
AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. doi: 10.1089/aid.2012.0322. Epub 2013 Feb 1.
7
In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus.在慢性感染猫免疫缺陷病毒的猫中，体内耗尽 CD4(+)CD25(hi) 调节性 T 细胞与改善抗病毒反应有关。
Virology. 2010 Aug 1;403(2):163-72. doi: 10.1016/j.virol.2010.04.016. Epub 2010 May 14.
8
Partial regulatory T cell depletion prior to acute feline immunodeficiency virus infection does not alter disease pathogenesis.在急性猫免疫缺陷病毒感染前进行部分调节性 T 细胞耗竭不会改变疾病发病机制。
PLoS One. 2011 Feb 25;6(2):e17183. doi: 10.1371/journal.pone.0017183.
9
CD4+CD25+ regulatory T cells are infected and activated during acute FIV infection.在急性猫免疫缺陷病毒感染期间，CD4+CD25+调节性T细胞会被感染并激活。
Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):263-72. doi: 10.1016/j.vetimm.2008.08.003. Epub 2008 Aug 22.
10
Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors.猫免疫缺陷病毒（FIV）对CD4+ CD25+ T调节细胞的优先感染与CXCR4的表面表达以及FIV长末端重复序列结合细胞转录因子的激活均相关。
J Virol. 2005 Apr;79(8):4965-76. doi: 10.1128/JVI.79.8.4965-4976.2005.

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Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis.猫逆转录病毒的合并感染与孢子丝菌病猫的免疫参数变化有关。
PLoS One. 2018 Nov 30;13(11):e0207644. doi: 10.1371/journal.pone.0207644. eCollection 2018.
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Investigation of immune cell markers in feline oral squamous cell carcinoma.猫口腔鳞状细胞癌中免疫细胞标志物的研究。
Vet Immunol Immunopathol. 2018 Aug;202:52-62. doi: 10.1016/j.vetimm.2018.06.011. Epub 2018 Jun 13.
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Applications of the FIV Model to Study HIV Pathogenesis.FIV 模型在研究 HIV 发病机制中的应用。
Viruses. 2018 Apr 20;10(4):206. doi: 10.3390/v10040206.
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Neurologic disease in feline immunodeficiency virus infection: disease mechanisms and therapeutic interventions for NeuroAIDS.猫免疫缺陷病毒感染的神经疾病：神经艾滋病的发病机制和治疗干预。
J Neurovirol. 2018 Apr;24(2):220-228. doi: 10.1007/s13365-017-0593-1. Epub 2017 Dec 15.
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Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration.猫免疫缺陷病毒神经发病机制：一种HIV诱导的中枢神经系统炎症和神经退行性变的模型。
Vet Sci. 2017 Mar 6;4(1):14. doi: 10.3390/vetsci4010014.
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Micro-RNA 10a Is Increased in Feline T Regulatory Cells and Increases Foxp3 Protein Expression Following In Vitro Transfection.微小RNA 10a在猫调节性T细胞中表达增加，体外转染后可增加叉头框蛋白3（Foxp3）的蛋白表达。
Vet Sci. 2017 Feb 21;4(1):12. doi: 10.3390/vetsci4010012.
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Changes of CD4+CD25+ cells ratio in immune organs from chickens challenged with infectious bursal disease virus strains with varying virulences.用不同毒力传染性法氏囊病病毒株攻击鸡后，其免疫器官中CD4+CD25+细胞比例的变化。
Viruses. 2015 Mar 20;7(3):1357-72. doi: 10.3390/v7031357.
9
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.调节性T细胞作为增强病毒性疾病疫苗效力的佐剂靶点。
Virusdisease. 2014 Jan;25(1):18-25. doi: 10.1007/s13337-013-0187-3. Epub 2013 Nov 29.

本文引用的文献

1
Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency.猫科动物富含糖蛋白A重复序列的锚定蛋白将转化生长因子β固定在活化的CD4(+)CD25(+)调节性T细胞表面，并介导艾滋病慢病毒诱导的T细胞免疫缺陷。
AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. doi: 10.1089/aid.2012.0322. Epub 2013 Feb 1.
2
Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).信号肽切割对于调节性 T 细胞表面蛋白富含亮氨酸重复序列 32（LRRC32）的表面表达至关重要。
BMC Biochem. 2011 May 26;12:27. doi: 10.1186/1471-2091-12-27.
3
CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism.CD4(+)CD25(+)调节性T细胞在急性和慢性猫免疫缺陷病毒感染期间利用膜转化生长因子-β依赖性机制抑制CD8(+)干扰素-γ的产生。
AIDS Res Hum Retroviruses. 2010 Feb;26(2):201-16. doi: 10.1089/aid.2009.0162.
4
Regulatory T cells and inhibitory cytokines in autoimmunity.自身免疫中的调节性T细胞和抑制性细胞因子。
Curr Opin Immunol. 2009 Dec;21(6):612-8. doi: 10.1016/j.coi.2009.09.011. Epub 2009 Oct 23.
5
CD4+CD25+ regulatory T cells are infected and activated during acute FIV infection.在急性猫免疫缺陷病毒感染期间，CD4+CD25+调节性T细胞会被感染并激活。
Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):263-72. doi: 10.1016/j.vetimm.2008.08.003. Epub 2008 Aug 22.
6
Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis.HIV-1感染与免疫发病机制中的Foxp3和调节性T细胞
Immunol Res. 2008;41(3):248-66. doi: 10.1007/s12026-008-8037-x.
7
Transforming growth factor-beta/transforming growth factor-betaRII signaling may regulate CD4+CD25+ T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection.转化生长因子-β/转化生长因子-β受体II信号传导可能调节猫艾滋病慢病毒感染中CD4+CD25+调节性T细胞的稳态和抑制功能。
J Acquir Immune Defic Syndr. 2008 Feb 1;47(2):148-60. doi: 10.1097/QAI.0b013e318160df70.
8
CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro.从感染HIV的个体中分离出的CD25 +调节性T细胞在体外可抑制HIV特异性CD8 + T细胞的细胞溶解和非细胞溶解抗病毒活性。
AIDS Res Hum Retroviruses. 2007 Mar;23(3):438-50. doi: 10.1089/aid.2006.0162.
9
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.猿猴免疫缺陷病毒诱导的淋巴组织纤维化由转化生长因子β1阳性调节性T细胞介导，并始于早期感染。
J Infect Dis. 2007 Feb 15;195(4):551-61. doi: 10.1086/510852. Epub 2007 Jan 8.
10
Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B.CD4+CD25+Foxp3+调节性T细胞与慢性乙型肝炎患者的病毒清除及疾病活动的关系
Int Immunol. 2007 Feb;19(2):133-40. doi: 10.1093/intimm/dxl130. Epub 2006 Dec 20.

猫免疫缺陷病毒感染直接激活 CD4+ CD25+ T 调节细胞。

Infection with feline immunodeficiency virus directly activates CD4+ CD25+ T regulatory cells.

机构信息

Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.

出版信息

J Virol. 2013 Aug;87(16):9373-8. doi: 10.1128/JVI.00996-13. Epub 2013 Jun 12.

DOI:10.1128/JVI.00996-13
PMID:23760252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3754053/
Abstract

Lentivirus infection activates CD4(+) CD25(+) T regulatory (Treg) cells. Activation of Treg cells may be due to direct virus infection or chronic antigenic stimulation. Herein we demonstrate that in vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates Treg cells as measured by immunosuppressive function and upregulation of GARP, FoxP3, and membrane-bound transforming growth factor β (TGF-β). These data demonstrate for the first time that AIDS lentiviruses infect and activate Treg cells, potentially contributing to immune dysfunction.

摘要

慢病毒感染会激活 CD4(+) CD25(+) T 调节（Treg）细胞。Treg 细胞的激活可能是由于直接的病毒感染或慢性抗原刺激。在此，我们证明体外猫免疫缺陷病毒（FIV）感染而非紫外线失活病毒会通过免疫抑制功能和 GARP、FoxP3 和膜结合转化生长因子β（TGF-β）的上调来激活 Treg 细胞。这些数据首次表明艾滋病慢病毒会感染和激活 Treg 细胞，这可能导致免疫功能障碍。