Reed Susan D, Lampe Johanna W, Qu Conghui, Copeland Wade K, Gundersen Gabrielle, Fuller Sharon, Newton Katherine M
From the 1Group Health Research Institute, University of Washington, Seattle, WA; and 2Fred Hutchinson Cancer Research Center, Seattle, WA.
Menopause. 2014 Feb;21(2):153-8. doi: 10.1097/GME.0b013e3182952228.
The prevalence of vasomotor symptoms (VMS) among women aged 45 years or older who report regular menses has not been described well. Variability by race/ethnicity is expected.
A cross-sectional analysis of Group Health enrollees was performed among women ages 45-56 y with regular and no skipped menses, and not taking hormones. Data were collected from electronic databases and mailed surveys, including a soy food questionnaire. Associations between race/ethnicity and VMS (ever/never; past 2 wk) were assessed using generalized linear models, controlling for age and body mass index. The prevalence of headache and joint pain, and VMS associations within race by soy intake were explored.
A total of 1,513 premenopausal women with a mean age of 48.5 years responded to the survey; 75% were white. Native American women were most likely to report ever having VMS (66.7%), followed by black (61.4%), white (58.3%), Hawaiian/Pacific Islander (45.5%), mixed-ethnicity (42.1%), Vietnamese (40.0%), Filipino (38.9%, P < 0.05), Japanese (35.9%, P < 0.01), East Indian (31.3%, P < 0.05), Chinese (29.0%, P < 0.001), and other Asian (25.6%, P < 0.001) women, as compared with white women. Hispanic women were less likely to have VMS (41.7%) than non-Hispanic white women (58.8%, P < 0.001). Among white women, but not among other women, soy intake was associated with VMS (P = 0.03).
Among a diverse population of premenopausal women, VMS prevalence is high at 55%. Asian (vs white) and Hispanic (vs non-Hispanic white) women are less likely to report ever having VMS, a pattern similar to that observed during the menopausal transition and early postmenopause in our studies. White women with more VMS seem to include more soy in their diet.
45岁及以上有规律月经的女性血管舒缩症状（VMS）的患病率尚未得到充分描述。预计种族/民族之间存在差异。
对健康集团的参保者进行横断面分析，研究对象为45至56岁有规律月经且无月经跳过、未服用激素的女性。数据从电子数据库和邮寄调查问卷中收集，包括一份大豆食品问卷。使用广义线性模型评估种族/民族与VMS（曾经/从未；过去2周）之间的关联，并控制年龄和体重指数。探讨头痛和关节痛的患病率，以及按大豆摄入量划分的种族内部VMS的关联。
共有1513名平均年龄为48.5岁的绝经前女性对调查做出了回应；75%为白人。美国原住民女性报告曾有VMS的可能性最高（66.7%），其次是黑人（61.4%）、白人（58.3%）、夏威夷/太平洋岛民（45.5%）、混合种族（42.1%）、越南人（40.0%）、菲律宾人（38.9%，P<0.05）、日本人（35.9%，P<0.01）、东印度人（31.3%，P<0.05）、中国人（29.0%，P<0.001）和其他亚洲人（25.6%，P<0.001）女性，与白人女性相比。西班牙裔女性出现VMS的可能性（41.7%）低于非西班牙裔白人女性（58.8%，P<0.001）。在白人女性中，但在其他女性中并非如此，大豆摄入量与VMS相关（P=0.03）。
在不同的绝经前女性群体中，VMS患病率高达55%。亚洲女性（与白人相比）和西班牙裔女性（与非西班牙裔白人相比）报告曾有VMS的可能性较小，这一模式与我们研究中绝经过渡期间和绝经后早期观察到的模式相似。有更多VMS的白人女性在饮食中似乎摄入了更多大豆。
