Research Institute of Science for Aging, Department of Food & Nutrition, College of Human Ecology, Yonsei University, 134 Shinchon-dong, Sudamun-Gu, 120-749 Seoul, Republic of Korea.
Food Funct. 2013 Aug;4(8):1223-8. doi: 10.1039/c3fo00006k.
The present study determined the effect of tagatose supplementation on postprandial hyperglycemia in normal (n = 54) and hyperglycemic subjects [n = 40, impaired fasting glucose (IFG) and newly diagnosed type 2 diabetes]. In a double-blind crossover designed study, study subjects were randomly assigned to consume a sucralose-erythritol drink (the placebo) or a tagatose-containing drink (the test) with a seven-day interval. Finally, 85 subjects completed the study (normal, n = 52; hyperglycemic, n = 33). Blood samples were collected at 0, 30, 60 and 120 min after ingestion and analyzed for fasting and postprandial levels of glucose, insulin and C-peptide. Basic anthropometric parameters and lipid files were also measured. Hyperglycemic subjects were basically older and heavier, and showed higher levels of triglyceride, total- and LDL-cholesterols and apolipoprotein AI and B compared with normal subjects. After consuming the tagatose (5 g)-containing drink, hyperglycemic subjects had a significant reduction in serum levels of glucose at 120 min (p = 0.019) and glucose area under the curve (AUC) (p = 0.017), however these were not observed in normal subjects. When ages were matched between the two groups, the glucose response patterns were shown to be similar. Additionally, normal subjects who received a high-dose of tagatose-containing drinks (10 g) showed significantly lower levels of insulin at 30 min (p = 0.004) and 60 min (p = 0.011), insulin AUC (p = 0.009), and C-peptide at 30 min (p = 0.004), 60 min (p = 0.011) and C-peptide AUC (p = 0.023). In conclusion, a single dietary supplement in the form of a tagatose-containing drink may be beneficial for controlling postprandial glycemic response in Koreans.
本研究旨在探讨塔格糖补充对正常（n=54）和高血糖受试者（n=40，空腹血糖受损[IFG]和新诊断的 2 型糖尿病）餐后高血糖的影响。在一项双盲交叉设计的研究中，研究对象被随机分配饮用含有三氯蔗糖和赤藓糖醇的饮料（安慰剂）或含有塔格糖的饮料（试验），两种饮料的饮用间隔为 7 天。最终，85 名受试者完成了研究（正常组，n=52；高血糖组，n=33）。在摄入后 0、30、60 和 120 分钟采集血样，分析空腹和餐后血糖、胰岛素和 C 肽水平。还测量了基本的人体测量参数和血脂谱。与正常组相比，高血糖组受试者年龄较大、体重较重，且甘油三酯、总胆固醇、LDL 胆固醇、载脂蛋白 AI 和 B 水平较高。在摄入含 5g 塔格糖的饮料后，高血糖组受试者 120 分钟时血清葡萄糖水平显著降低（p=0.019），血糖曲线下面积（AUC）显著降低（p=0.017），但在正常组中未观察到这一结果。当两组受试者的年龄匹配时，发现葡萄糖的应答模式相似。此外，正常组受试者在摄入高剂量（10g）含塔格糖的饮料后，30 分钟（p=0.004）和 60 分钟（p=0.011）时胰岛素水平显著降低，胰岛素 AUC（p=0.009）和 30 分钟（p=0.004）、60 分钟（p=0.011）和 C 肽 AUC（p=0.023）也显著降低。综上所述，单次摄入含塔格糖的饮食补充剂可能有益于控制韩国人的餐后血糖反应。
