Life Science Division, AU-KBC Research Centre, MIT Campus of Anna University, Chromepet, Chennai 600044, India.
Food Funct. 2013 Aug;4(8):1148-84. doi: 10.1039/c3fo30317a.
Several antioxidants and agents having similar antioxidant effects are known to exert beneficial effects in ameliorating the injurious effects of hyperglycemia on liver in different diabetic in vitro and in vivo models. The review deals with some of the agents which have been shown to exert protective effects on liver against hyperglycemic insult and the various mechanisms involved. The different classes of agents which protect the diabetic liver or decrease the severity of hyperglycemia mediated injury include flavonoids, catechins, and other polyphenolic compounds, curcumin and its derivatives, certain vitamins, hormones and drugs, trace elements, prototypical antioxidants and amino acids. Some of the pronounced changes mediated by the antioxidants in liver exposed to hyperglycemia include decreased oxidative stress, and alterations in carbohydrate and lipid metabolism. Other mechanisms through which the agents ameliorate hyperglycemia mediated liver injury include decrease in oxidative DNA and protein damage, restoration of mitochondrial structural and functional integrity, decrease in inflammation and improved insulin signaling. Thus, antioxidants may prove to be an important mode of defense in maintaining normal hepatic functions in diabetes.
几种具有相似抗氧化作用的抗氧化剂已被证实可在不同的糖尿病体外和体内模型中减轻高血糖对肝脏的损伤作用。本综述涉及一些已被证明可对肝脏起到保护作用、防止高血糖损伤以及涉及的各种机制的药物。可保护糖尿病肝脏或降低高血糖介导损伤严重程度的不同药物类别包括类黄酮、儿茶素和其他多酚化合物、姜黄素及其衍生物、某些维生素、激素和药物、微量元素、典型抗氧化剂和氨基酸。在暴露于高血糖的肝脏中，抗氧化剂介导的一些明显变化包括氧化应激减少，以及碳水化合物和脂质代谢改变。药物改善高血糖介导的肝脏损伤的其他机制包括减少氧化 DNA 和蛋白质损伤、恢复线粒体结构和功能完整性、减少炎症和改善胰岛素信号。因此，抗氧化剂可能在维持糖尿病中正常肝脏功能方面被证明是一种重要的防御方式。
