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特立帕肽治疗隐性营养不良型大疱性表皮松解症患者的严重骨质疏松症。

Severe osteoporosis treated with teriparatide in a patient affected by recessive epidermolysis bullosa dystrophica.

机构信息

Orthopedic and Traumatology Unit, Department of Clinical Methodology and Surgical Techniques, University of Bari, Bari, Italy.

出版信息

Osteoporos Int. 2011 Mar;22(3):1003-6. doi: 10.1007/s00198-010-1278-2. Epub 2010 May 11.

DOI:10.1007/s00198-010-1278-2
PMID:20458569
Abstract

In this work, we describe the clinical and instrumental results of our experience, the first reported in the literature, of the administration of teriparatide to treat severe osteoporosis secondary to epidermolysis bullosa. Already after 2 months of therapy, the patient, a 20-year-old affected by a recessive form of epidermolysis bullosa dystrophica, had less pain and a functional recovery resulting in an improved autonomy; a satisfactory increase in the densitometric values was documented.

摘要

在这项工作中,我们描述了我们的经验的临床和仪器结果,这是文献中首次报道的用特立帕肽治疗大疱性表皮松解症继发的严重骨质疏松症。在治疗 2 个月后,患者,一名 20 岁的隐性营养不良性大疱性表皮松解症患者,疼痛减轻,功能恢复,从而提高了生活的自主性;骨密度值的显著增加得到了证实。

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引用本文的文献

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Retrospective longitudinal study of osteoporosis in adults with recessive dystrophic epidermolysis bullosa.对隐性营养不良性大疱性表皮松解症成人患者骨质疏松症的回顾性纵向研究。
Clin Case Rep. 2018 Nov 12;7(1):58-63. doi: 10.1002/ccr3.1898. eCollection 2019 Jan.

本文引用的文献

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Maxillary alveolar process fracture complicating intubation in a patient with epidermolysis bullosa.
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News from the first regional symposium on hereditary epidermolysis bullosa (Mediterranean - Central and Eastern Europe).
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Severe symptomatic hypocalcemia in a patient with RDEB treated with intravenous zoledronic acid.
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Medical management of epidermolysis bullosa: Proceedings of the IInd International Symposium on Epidermolysis Bullosa, Santiago, Chile, 2005.大疱性表皮松解症的医学管理:第二届国际大疱性表皮松解症研讨会会议记录,智利圣地亚哥,2005年
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Bone mineralization in children with epidermolysis bullosa.大疱性表皮松解症患儿的骨矿化
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Osteoporosis: a review.骨质疏松症:综述
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Osteoporosis in a patient with recessive dystrophic epidermolysis bullosa.
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Prognostic implications of determining 180 kDa bullous pemphigoid antigen (BPAG2) gene/protein pathology in neonatal junctional epidermolysis bullosa.
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GB3 monoclonal antibody for the diagnosis of junctional epidermolysis bullosa: results of a multicenter study.用于诊断交界性大疱性表皮松解症的GB3单克隆抗体:一项多中心研究的结果
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