T 细胞衰老的两面性——自身免疫与免疫缺陷。
The janus head of T cell aging - autoimmunity and immunodeficiency.
机构信息
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine , Stanford, CA , USA ; Department of Medicine, Palo Alto Veteran Administration Health Care System , Palo Alto, CA , USA.
出版信息
Front Immunol. 2013 Jun 4;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013.
Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in the elderly. Why an immune system that suboptimally responds to exogenous antigen fails to maintain tolerance to self-antigens appears to be perplexing. In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum.
免疫衰老最为人所知的是其免疫缺陷，这会增加感染易感性，并降低对疫苗接种的适应性免疫反应。与此同时，衰老的免疫系统容易发生自身免疫反应，许多自身免疫性疾病的发病率随着年龄的增长而增加，甚至在老年人中更为常见。为什么一个对外源抗原反应不佳的免疫系统不能维持对自身抗原的耐受性，这似乎令人费解。在这篇综述中，我们将讨论与免疫反应谱和信号通路调节相关的与年龄相关的偏差，这可能有助于阐明这一难题。
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