Yuan Wanqiong, Song Chunli
Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Beijing Key Laboratory of Spinal Disease, Beijing, China.
Med Rev (2021). 2022 Sep 15;2(4):331-348. doi: 10.1515/mr-2022-0018. eCollection 2022 Aug.
Bone has long been considered as a silent organ that provides a reservoir of calcium and phosphorus, traditionally. Recently, further study of bone has revealed additional functions as an endocrine organ connecting systemic organs of the whole body. Communication between bone and other organs participates in most physiological and pathological events and is responsible for the maintenance of homeostasis. Here, we present an overview of the crosstalk between bone and other organs. Furthermore, we describe the factors mediating the crosstalk and review the mechanisms in the development of potential associated diseases. These connections shed new light on the pathogenesis of systemic diseases and provide novel potential targets for the treatment of systemic diseases.
长期以来，骨骼一直被传统地认为是一个提供钙和磷储存库的沉默器官。最近，对骨骼的进一步研究揭示了它作为连接全身各系统器官的内分泌器官的额外功能。骨骼与其他器官之间的交流参与了大多数生理和病理过程，并负责维持体内平衡。在此，我们概述骨骼与其他器官之间的相互作用。此外，我们描述了介导这种相互作用的因素，并回顾了潜在相关疾病发生发展的机制。这些联系为全身性疾病的发病机制提供了新的见解，并为全身性疾病的治疗提供了新的潜在靶点。
