Tuscia University, Department of Ecological and Biological Sciences, Largo dell'Università, 01100 Viterbo, Italy.
Biomed Res Int. 2013;2013:310186. doi: 10.1155/2013/310186. Epub 2013 May 23.
ω -3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These data suggest that DHA can exert antitumor activity potentially representing an effective adjuvant in cancer chemotherapy. This review is focused on current knowledge supporting the potential use of DHA for the enhancement of the efficacy of anticancer treatments in relation to its ability to enhance the uptake of anticancer drugs, regulate the oxidative status of tumor cells, and inhibit tumor cell invasion and metastasis.
ω-3 多不饱和脂肪酸（PUFAs）主要存在于鱼油中，是人类饮食的一部分。在 PUFAs 中，二十二碳六烯酸（DHA）因其抗炎、抗增殖、促凋亡、抗血管生成、抗侵袭和抗转移特性而受到特别关注。这些数据表明，DHA 可以发挥抗肿瘤活性，有可能成为癌症化疗的有效辅助剂。本综述重点介绍了目前支持 DHA 潜在用途的知识，这些用途与增强抗癌药物摄取、调节肿瘤细胞氧化状态以及抑制肿瘤细胞侵袭和转移的能力有关。
