Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
J Diabetes Res. 2013;2013:787084. doi: 10.1155/2013/787084. Epub 2013 May 22.
We have previously shown that dental caries may be produced in diabetic rodent models fed with noncariogenic standard diets; however, many studies usually add large amounts of sugar to the diet to induce dental caries. Moreover, the physical properties of cariogenic diets have been reported as an important factor in the formation of caries. The aim of this study was to clarify the effect of the hardness of non-cariogenic diets on the development of dental caries in diabetic rodents. Seven-week-old female F344 rats were divided into 4 groups: intact rats fed with a standard pelletized or powdered diet and alloxan-induced diabetic rats fed with a standard pelletized or powdered diet. All of the rats were sacrificed at 52 weeks of age for morphological examinations on their dental tissue. Dental caries had developed and extended to all the molars in the diabetic rats that were fed with both the pelletized and powdered diets. Moreover, the lesion was significantly enhanced in the powdered diet group compared to that in the pelletized diet group. In conclusion, food hardness is an important factor influencing the development of dental caries in diabetic rats.
我们之前已经表明，在给予非致龋标准饮食的糖尿病啮齿动物模型中可能会产生龋齿；然而，许多研究通常会在饮食中添加大量的糖来诱导龋齿。此外，致龋饮食的物理特性已被报道为龋齿形成的一个重要因素。本研究旨在阐明非致龋饮食的硬度对糖尿病啮齿动物龋齿发展的影响。将 7 周龄雌性 F344 大鼠分为 4 组：给予标准颗粒或粉末饮食的完整大鼠和给予标准颗粒或粉末饮食的链脲佐菌素诱导的糖尿病大鼠。所有大鼠在 52 周龄时处死，用于其牙组织的形态学检查。糖尿病大鼠在给予颗粒和粉末饮食时均发生并扩展至所有磨牙龋齿，且在粉末饮食组中病变明显比颗粒饮食组更严重。总之，食物硬度是影响糖尿病大鼠龋齿发展的一个重要因素。
