Kumar Manoj, Nagpal Ravinder, Hemalatha R, Verma Vinod, Kumar Ashok, Singh Satvinder, Marotta Francesco, Jain Shalini, Yadav Hariom
Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, India.
Acta Biomed. 2012 Dec;83(3):220-33.
For decades, the hallmark of medical treatment for cancer has been intravenous cytotoxic chemotherapy, where these drugs target rapidly dividing cells, including cancer cells and certain normal tissues. As a result, many patients experience the classic toxicities of alopecia, gastrointestinal symptoms, and myelosuppression. In the past decade, however, a dramatic shift has been witnesses in the cancer therapy. Although traditional cytotoxic chemotherapy still remains the treatment of choice for many malignancies, targeted therapies are now a component of treatment for many types of cancer, including breast, colorectal, lung, and pancreatic cancers, as well as lymphoma, leukemia, and multiple myeloma.
几十年来,癌症医学治疗的标志一直是静脉内细胞毒性化疗,这些药物靶向快速分裂的细胞,包括癌细胞和某些正常组织。因此,许多患者会经历脱发、胃肠道症状和骨髓抑制等典型毒性反应。然而,在过去十年中,癌症治疗领域发生了巨大转变。尽管传统的细胞毒性化疗仍然是许多恶性肿瘤的首选治疗方法,但靶向治疗现在已成为许多类型癌症治疗的一部分,包括乳腺癌、结直肠癌、肺癌和胰腺癌,以及淋巴瘤、白血病和多发性骨髓瘤。