Tutton P J
Cell Tissue Kinet. 1975 May;8(3):259-66. doi: 10.1111/j.1365-2184.1975.tb01224.x.
The influence of nerve stimulation and sham-stimulation on the mitotic rate in epithelial cells lining the crypts of Lieberkühn in the jejunum of anaesthetized rats was studied. Administration of the anaesthetic and opening the abdominal cavity was without significant effect on the crypt cell mitotic rate. However, externalizing a loop of jejunum and applying sham-stimuli to its mesenteric nerves resulted in a significant decrease in the crypt cell mitotic rate in that loop. Application of electrical stimuli to the mesenteric nerves of another externalized jejunal loop resulted in a significant increase in the mitotic rate in the crypt cells of that segment. Similar acceleration of crypt cell proliferation by electrical stimuli applied to mesenteric nerves was also seen in chemically sympathectomized rats.
研究了神经刺激和假刺激对麻醉大鼠空肠中利伯库恩隐窝内衬上皮细胞有丝分裂率的影响。给予麻醉药和打开腹腔对隐窝细胞有丝分裂率无显著影响。然而，将一段空肠外置并对其肠系膜神经施加假刺激，导致该段空肠隐窝细胞有丝分裂率显著降低。对另一段外置空肠的肠系膜神经施加电刺激，导致该段隐窝细胞有丝分裂率显著增加。在化学去交感神经大鼠中，对肠系膜神经施加电刺激也观察到隐窝细胞增殖有类似的加速现象。
