生物性别对心脏病理生理学的影响。
Effects of biological sex on the pathophysiology of the heart.
机构信息
UMR-S 942, Inserm, Paris, France; University Paris-Diderot, Paris, France.
出版信息
Br J Pharmacol. 2014 Feb;171(3):555-66. doi: 10.1111/bph.12279.
Abstract
Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular pathophysiology have long been known, the sex-specific mechanisms mediating these processes have been further elucidated over recent years. This review aims at analysing the sex-based differences in cardiac structure and function in adult mammals, and the sex-based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex-based difference is a variable that should be dealt with, not only in basic science or clinical research, but also with regards to therapeutic approaches.
摘要
心血管疾病是工业化国家中男女的主要死因。尽管生物性别对心血管病理生理学的影响早已为人所知，但近年来，介导这些过程的性别特异性机制得到了进一步阐明。本篇综述旨在分析成年哺乳动物心脏结构和功能的性别差异，以及心脏对病理情况反应中涉及的主要分子机制的性别差异。从这篇综述中可以看出，性别差异是一个应该被处理的变量，不仅在基础科学或临床研究中，而且在治疗方法方面也是如此。
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