UMR-S 942, Inserm, Paris, France; University Paris-Diderot, Paris, France.
Br J Pharmacol. 2014 Feb;171(3):555-66. doi: 10.1111/bph.12279.
Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular pathophysiology have long been known, the sex-specific mechanisms mediating these processes have been further elucidated over recent years. This review aims at analysing the sex-based differences in cardiac structure and function in adult mammals, and the sex-based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex-based difference is a variable that should be dealt with, not only in basic science or clinical research, but also with regards to therapeutic approaches.
心血管疾病是工业化国家中男女的主要死因。尽管生物性别对心血管病理生理学的影响早已为人所知，但近年来，介导这些过程的性别特异性机制得到了进一步阐明。本篇综述旨在分析成年哺乳动物心脏结构和功能的性别差异，以及心脏对病理情况反应中涉及的主要分子机制的性别差异。从这篇综述中可以看出，性别差异是一个应该被处理的变量，不仅在基础科学或临床研究中，而且在治疗方法方面也是如此。
