William Harvey Research Institute, Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
Br J Pharmacol. 2012 Sep;167(2):298-312. doi: 10.1111/j.1476-5381.2012.02036.x.
Approximately one third of all deaths are attributed to cardiovascular disease (CVD), making it the biggest killer worldwide. Despite a number of therapeutic options available, the burden of CVD morbidity continues to grow indicating the need for continued research to address this unmet need. In this respect, investigation of the mechanisms underlying the protection that premenopausal females enjoy from cardiovascular-related disease and mortality is of interest. In this review, we discuss the essential role that rodent animal models play in enabling this field of research. In particular, we focus our discussion on models of hypertension and atherosclerosis.
大约三分之一的死亡归因于心血管疾病(CVD),使其成为全球最大的杀手。尽管有许多治疗选择可用,但 CVD 发病率的负担仍在继续增加,这表明需要继续研究以满足这一未满足的需求。在这方面,研究绝经前女性免受心血管疾病和死亡率影响的保护机制是很有意义的。在这篇综述中,我们讨论了啮齿动物模型在推动这一研究领域中的重要作用。特别是,我们集中讨论了高血压和动脉粥样硬化模型。