Naz Samia, Mushtaq Asma, Rehman Saira, Bari Attia, Maqsud Amnah, Khan Muhammad Zeeshan, Ahmad Tahir Masood
Department of Paediatric Medicine , The Children's Hospital and The Institute of Child Health, Lahore.
J Coll Physicians Surg Pak. 2013 Jun;23(6):409-12.
To determine the spectrum of clinical presentation, laboratory parameters and drug therapy in patients with Juvenile Rheumatoid Arthritis (JRA).
Case series.
The Children's Hospital and The Institute of Child Health, Lahore, from October 2008 to October 2011.
All patients who fulfilled the American College of Rheumatology criteria for JRA were enrolled. Their clinical features, investigations done and treatment received for JRA were noted. Statistical analysis of data was done on SPSS version 16.0 for obtaining descriptive statistics.
Out of 185 patients, 50.3% (n = 93) were females; 54% (n = 100) were between 10 - 15 years of age. Polyarthritis was found in 71.9% (n = 133) followed by oligoarthritis (22.7%, n = 42) and systemic onset disease (5.4%, n = 10). Morning stiffness (78%) and fever (68%) were the most common clinical presentations. All patients with systemic onset disease had fever (n = 10) followed by skin rash, hepatosplenomegaly and lymphadenopathy. Uveitis was found in 2 patients, and both belonged to the oligoarticular group. Rheumatoid factor was found in 10.27% (n = 19) of all patients. All patients were given non-steroidal anti-inflammatory drugs (NSAIDs). Disease modifying agents (methotrexate) were given to 43.8% (n = 81). Steroids were used in 61% (n = 113) of patients either with NSAIDs alone or NSAIDs plus methotrexate.
Disease profile of JRA at the study centre showed that polyarthritis is the commonest type. Recognition of subtypes will help in planning the management of these patients.
确定青少年类风湿性关节炎（JRA）患者的临床表现谱、实验室参数及药物治疗情况。
病例系列研究。
2008年10月至2011年10月期间，拉合尔儿童医院及儿童健康研究所。
纳入所有符合美国风湿病学会JRA标准的患者。记录其JRA的临床特征、所做检查及接受的治疗。使用SPSS 16.0版软件对数据进行统计分析以获取描述性统计结果。
185例患者中，50.3%（n = 93）为女性；54%（n = 100）年龄在10 - 15岁之间。多关节炎患者占71.9%（n = 133），其次是少关节炎（22.7%，n = 42）和全身型疾病（5.4%，n = 10）。晨僵（78%）和发热（68%）是最常见的临床表现。所有全身型疾病患者均有发热（n = 10），其次是皮疹、肝脾肿大和淋巴结病。2例患者出现葡萄膜炎，均属于少关节型组。所有患者中10.27%（n = 19）类风湿因子呈阳性。所有患者均给予非甾体抗炎药（NSAIDs）。43.8%（n = 81）的患者使用了病情改善药物（甲氨蝶呤）。61%（n = 113）的患者单独使用NSAIDs或NSAIDs加甲氨蝶呤的同时使用了类固醇。
研究中心JRA的疾病谱显示多关节炎是最常见的类型。识别亚型有助于规划这些患者的管理。
