Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Prog Mol Biol Transl Sci. 2013;118:243-65. doi: 10.1016/B978-0-12-394440-5.00010-3.
Visual arrestins are well known for their function in quenching the phototransduction process in rods and cones. Perhaps not as well known is their participation in multiple other processes in the normal and disease states of the eye. This chapter covers the range of the known functions of the visual arrestins, beginning with their classical role in quenching light-activated visual pigments. The role of visual arrestins is also reviewed from the perspective of their dynamic mobility whereby they redistribute significantly between the compartments of highly polarized photoreceptor cells. Additional roles of the visual arrestins are also reviewed based on new interacting partners that have been discovered over the past decade. Finally, the contribution of the visual arrestins to diseases of the visual system is explored.
视觉 arrestins 以其在光感受器细胞的光转化过程中发挥的作用而闻名。也许不太为人所知的是，它们在眼睛的正常和病变状态下参与了多种其他过程。本章涵盖了已知的视觉 arrestins 的功能范围，首先介绍了它们在淬灭光激活视觉色素中的经典作用。还从视觉 arrestins 的动态迁移性的角度回顾了它们的作用，即它们在高度极化的光感受器细胞的隔室之间显著重新分布。根据过去十年发现的新相互作用伙伴，还回顾了视觉 arrestins 的其他作用。最后，探讨了视觉 arrestins 对视觉系统疾病的贡献。
