促吞噬素与乙肝病毒表面蛋白序列之间的竞争

Competition between tuftsin and HBV S-protein sequences.

作者信息

Siemion I Z, Słoń J, Nawrocka E, Wieczorek Z

机构信息

Institute of Chemistry, Wrocław University, Poland.

出版信息

Int J Pept Protein Res. 1990 May;35(5):428-33. doi: 10.1111/j.1399-3011.1990.tb00069.x.

DOI:10.1111/j.1399-3011.1990.tb00069.x

PMID:2376468

Abstract

The syntheses of HBV S-protein partial sequences: Thr-Lys-Pro-Thr (I), Thr-Lys-Pro-Thr-Asp (II), and Thr-Lys-Pro-Thr-Asp-Gly (III) and also of pentapeptide Thr-Lys-Pro-Gly-Arg (IV), are described. For the peptides II and III inhibitory activity against tuftsin was found. Peptide IV (an analogue of tuftsin-inhibitor Thr-Lys-Pro-Pro-Arg) demonstrated a tuftsin-like activity in the phagocytosis experiments.

摘要

描述了乙肝病毒表面抗原（HBV S-protein）部分序列：苏氨酸-赖氨酸-脯氨酸-苏氨酸（I）、苏氨酸-赖氨酸-脯氨酸-苏氨酸-天冬氨酸（II）和苏氨酸-赖氨酸-脯氨酸-苏氨酸-天冬氨酸-甘氨酸（III）以及五肽苏氨酸-赖氨酸-脯氨酸-甘氨酸-精氨酸（IV）的合成。发现肽II和III对促吞噬肽有抑制活性。在吞噬作用实验中，肽IV（促吞噬肽抑制剂苏氨酸-赖氨酸-脯氨酸-脯氨酸-精氨酸的类似物）表现出类似促吞噬肽的活性。