Center of Obesity and Eating Disorders, Stella Maris Mediterraneum Foundation, Chiaromonte, Potenza, Italy.
Ageing Res Rev. 2013 Sep;12(4):996-1004. doi: 10.1016/j.arr.2013.05.007. Epub 2013 Jun 11.
Several epidemiologic studies have implicated visceral fat as a major risk factor for insulin resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome and death. Utilizing novel models of visceral obesity, numerous studies have demonstrated that the relationship between visceral fat and longevity is causal while the accrual of subcutaneous fat does not appear to play an important role in the etiology of disease risk. Specific recommended intake levels vary based on a number of factors, including current weight, activity levels, and weight loss goals. It is discussed the need of reducing the visceral fat as a potential treatment strategy to prevent or delay age-related diseases and to increase longevity.
多项流行病学研究表明,内脏脂肪是胰岛素抵抗、2 型糖尿病、心血管疾病、中风、代谢综合征和死亡的主要危险因素。利用内脏肥胖的新模型,许多研究表明,内脏脂肪与长寿之间的关系是因果关系,而积累的皮下脂肪似乎在疾病风险的病因中不起重要作用。具体的推荐摄入量因许多因素而异,包括当前体重、活动水平和减肥目标。文中讨论了减少内脏脂肪作为一种潜在治疗策略的必要性,以预防或延缓与年龄相关的疾病并延长寿命。