Department of Kinesiology and Health Studies, Southeastern Louisiana University, SLU10845, Hammond, LA 70402, USA.
Eur J Appl Physiol. 2013 Sep;113(9):2401-8. doi: 10.1007/s00421-013-2677-9. Epub 2013 Jun 14.
Prolonged exercise requires increased utilization of blood glucose and adjustment of glucoregulatory hormones. Estrogen can reduce hepatic gluconeogenesis which could affect insulin concentrations. Amylin is co-secreted with insulin and controls influx of glucose into the blood.
To determine the effect of menstrual cycle stage on glucose, leptin, and pancreatic hormone responses to prolonged (90 min) exercise.
Five healthy, eumenorrheic women (24.6 ± 5.1 years; 67.4 ± 1 kg) were monitored for 3 months to determine menstrual cycle length. Subjects completed a preliminary session to determine exercise workloads and, in a fasted condition, completed two randomized 90-min treadmill exercise trials at 60 % VO2max during the early follicular (EFX) and mid-luteal phase (MLX) of their menstrual cycle. Blood samples were analyzed for glucose, insulin, C-peptide, amylin, glucagon, leptin, and cortisol concentrations at rest (-30 and 0 min), during exercise (18, 36, 54, 72, and 90 min) and after 20 min of recovery.
No changes in amylin, leptin, or cortisol occurred for EFX and MLX trials. A significant (p < 0.05) time effect occurred for glucose, insulin, and glucagon with reduced insulin across the exercise trial and increases in glucose and glucagon later in the trial, but there were no differences between the EFX and MLX trials.
Menstrual cycle stage does not affect glucose, insulin, C-peptide, amylin, glucagon, cortisol, and leptin responses to prolonged exercise; however, the exercise reduces insulin and increases glucose and glucagon concentrations. This is the first study to determine acute effects of exercise on amylin and other glucoregulatory hormone responses in women.
长时间运动需要增加血糖的利用和调节糖调节激素。雌激素可以减少肝糖异生，从而影响胰岛素浓度。胰岛淀粉样多肽与胰岛素一起被分泌，并控制葡萄糖流入血液。
确定月经周期阶段对延长（90 分钟）运动后血糖、瘦素和胰腺激素反应的影响。
监测 5 名健康、月经正常的女性（24.6±5.1 岁；67.4±1 公斤）3 个月，以确定月经周期长度。受试者完成了一个初步的会议来确定运动工作量，并在禁食条件下，在月经周期的早期卵泡（EFX）和中期黄体（MLX）阶段，以 60%的 VO2max 完成了两个随机的 90 分钟跑步机运动试验。在休息时（-30 和 0 分钟）、运动时（18、36、54、72 和 90 分钟）和 20 分钟恢复后，分析血液样本中的葡萄糖、胰岛素、C 肽、胰岛淀粉样多肽、胰高血糖素、瘦素和皮质醇浓度。
EFX 和 MLX 试验中，胰岛淀粉样多肽、瘦素或皮质醇均无变化。葡萄糖、胰岛素和胰高血糖素出现显著（p<0.05）时间效应，运动过程中胰岛素降低，试验后期葡萄糖和胰高血糖素增加，但 EFX 和 MLX 试验之间无差异。
月经周期阶段不影响葡萄糖、胰岛素、C 肽、胰岛淀粉样多肽、胰高血糖素、皮质醇和瘦素对长时间运动的反应；然而，运动降低了胰岛素，增加了葡萄糖和胰高血糖素的浓度。这是第一项确定女性急性运动对胰岛淀粉样多肽和其他糖调节激素反应的研究。
