Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Sport and Exercise Science, University of Surrey, Leggett Building, Guildford, GU2 7WG, UK.
Eur J Appl Physiol. 2021 Nov;121(11):2993-3003. doi: 10.1007/s00421-021-04754-w. Epub 2021 Jul 8.
Variations in substrate metabolism have been identified in women during continuous steady-state aerobic exercise performed at the same relative intensity throughout discrete phases of the menstrual cycle, although some evidence exists that this is abolished when carbohydrate is ingested. This investigation examined the effects of a supraphysiologic exogenous glucose infusion protocol, administered during two phases of the menstrual cycle (follicular and luteal) in eumenorrheic women to identify differences between metabolic, hormonal and substrate oxidative responses.
During the experimental conditions, blood glucose was infused intravenously at rates to "clamp" blood glucose at 10 mM in seven healthy females (age 20 ± 1 y, mass 55.0 ± 4.1 kg, [Formula: see text] 40.0 ± 1.8 ml/kg/min). Following 30 min of seated rest, participants exercised on a cycle ergometer for 90 min at 60% [Formula: see text]. During the rest period and throughout exercise, blood metabolites and hormones were collected at regular intervals, in addition to expired air for the measurement of substrate oxidation.
Significant differences between ovarian hormones and menstrual phase were identified, with estrogen significantly higher during the luteal phase compared to the follicular phase (213.28 ± 30.70 pmol/l vs 103.86 ± 13.85 pmol/l; p = 0.016), and for progesterone (14.23 ± 4.88 vs 2.11 ± 0.36 nmol/l; p = 0.042). However, no further significance was identified in any of the hormonal, metabolite or substrate utilisation patterns between phases.
These data demonstrate that the infusion of a supraphysiological glucose dose curtails any likely metabolic influence employed by the fluctuation of ovarian hormones in eumenorrheic women during moderate exercise.
尽管有证据表明，在摄入碳水化合物时，这种情况会消失，但在整个月经周期的不同阶段，持续稳态有氧运动的相对强度相同，女性的底物代谢会发生变化。本研究在月经周期的两个阶段（卵泡期和黄体期）对生育期正常女性进行超生理外源性葡萄糖输注方案，以确定代谢、激素和底物氧化反应之间的差异。
在实验条件下，将静脉内输注血糖，以使 7 名健康女性（年龄 20 ± 1 岁，体重 55.0 ± 4.1kg，[公式：见正文]40.0 ± 1.8ml/kg/min）的血糖“钳夹”在 10mM。休息 30 分钟后，参与者以 60%[公式：见正文]的速度在自行车测功机上运动 90 分钟。在休息期间和整个运动过程中，每隔一段时间收集血液代谢物和激素，并采集呼出空气以测量底物氧化。
确定了卵巢激素和月经周期之间的显著差异，与卵泡期相比，黄体期雌激素明显升高（213.28 ± 30.70 pmol/l 比 103.86 ± 13.85 pmol/l；p = 0.016），孕激素也明显升高（14.23 ± 4.88 比 2.11 ± 0.36 nmol/l；p = 0.042）。然而，在任何激素、代谢物或底物利用模式之间，都没有发现进一步的意义。
这些数据表明，在生育期正常女性进行中等强度运动时，输注超生理剂量的葡萄糖会限制卵巢激素波动可能产生的代谢影响。
