P 物质增强表达全长神经激肽-1 受体的人胎脑神经细胞培养物中的 HIV-1 感染。
Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor.
机构信息
Research Institute, Children's Hospital of Philadelphia, Suite 1208, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.
出版信息
J Neurovirol. 2013 Jun;19(3):219-27. doi: 10.1007/s13365-013-0166-x. Epub 2013 Jun 14.
Abstract
The associations between the neurokinin-1 receptor (NK-1R), substance P (SP), and HIV-1 were investigated in neurosphere-derived cultures of microglial-depleted human fetal brain cells (HFBC). Full-length NK-1R was identified in HFBC cultures. SP treatment of the HFBC increased intracellular calcium mobilization and decreased electrical impedance, both of which were blocked by the NK-1R antagonist aprepitant. SP treatment of HIV-1-infected HFBC upregulated HIV-1 expression. These data show that human neural cells grown from neurospheres express functional full length NK-1R that is responsive to SP, and that SP enhanced HIV-1 infection in HBFC.
摘要
研究人员调查了神经激肽-1 受体（NK-1R）、P 物质（SP）与 HIV-1 之间的关联，研究对象是从小鼠大脑细胞中分离出的少突胶质细胞神经球衍生培养物。研究人员在 HFBC 培养物中鉴定出全长 NK-1R。SP 处理 HFBC 会增加细胞内钙动员，并降低电阻抗，这两种反应均被 NK-1R 拮抗剂 aprepitant 阻断。SP 处理 HIV-1 感染的 HFBC 会上调 HIV-1 的表达。这些数据表明，从神经球中生长的人神经细胞表达功能性全长 NK-1R，对 SP 有反应，并且 SP 增强了 HBFC 中的 HIV-1 感染。
相似文献
1
Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor.P 物质增强表达全长神经激肽-1 受体的人胎脑神经细胞培养物中的 HIV-1 感染。
J Neurovirol. 2013 Jun;19(3):219-27. doi: 10.1007/s13365-013-0166-x. Epub 2013 Jun 14.
2
Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo.肝癌细胞表达截断的神经激肽-1 受体，阿瑞匹坦可在体外和体内抑制其生长。
J Hepatol. 2014 May;60(5):985-94. doi: 10.1016/j.jhep.2013.12.024. Epub 2014 Jan 8.
3
Substance P accelerates the progression of human esophageal squamous cell carcinoma via MMP-2, MMP-9, VEGF-A, and VEGFR1 overexpression.P 物质通过 MMP-2、MMP-9、VEGF-A 和 VEGFR1 的过表达加速人食管鳞癌细胞的进展。
Mol Biol Rep. 2020 Jun;47(6):4263-4272. doi: 10.1007/s11033-020-05532-1. Epub 2020 May 20.
4
The substance P/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists.肺癌中的 P 物质/神经激肽-1 受体系统：聚焦于神经激肽-1 受体拮抗剂的抗肿瘤作用。
Peptides. 2012 Dec;38(2):318-25. doi: 10.1016/j.peptides.2012.09.024. Epub 2012 Sep 28.
5
The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer.神经激肽-1受体拮抗剂阿瑞匹坦是治疗乳腺癌的一个有前景的候选药物。
Int J Oncol. 2014 Oct;45(4):1658-72. doi: 10.3892/ijo.2014.2565. Epub 2014 Jul 28.
6
Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.生长抑素类似物伐普肽通过与神经激肽-1 受体相互作用在体外表现出生物效应。
Neuroimmunomodulation. 2013;20(5):247-55. doi: 10.1159/000350468. Epub 2013 Jul 5.
7
Neurokinin-1 receptor antagonist (aprepitant) inhibits drug-resistant HIV-1 infection of macrophages in vitro.神经激肽-1受体拮抗剂（阿瑞匹坦）在体外可抑制巨噬细胞对耐药性HIV-1的感染。
J Neuroimmune Pharmacol. 2007 Mar;2(1):42-8. doi: 10.1007/s11481-006-9059-6. Epub 2007 Jan 12.
8
The Repurposing of Non-Peptide Neurokinin-1 Receptor Antagonists as Antitumor Drugs: An Urgent Challenge for Aprepitant.非肽类神经激肽-1 受体拮抗剂的再利用作为抗肿瘤药物：阿瑞匹坦面临的紧迫挑战。
Int J Mol Sci. 2023 Nov 3;24(21):15936. doi: 10.3390/ijms242115936.
9
Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.单核细胞/巨噬细胞分化过程中全长和截短型神经激肽-1受体的表达与功能
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7771-6. doi: 10.1073/pnas.0602563103. Epub 2006 May 4.
10
Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals.神经激肽-1 受体拮抗剂阿瑞匹坦抗 HIV-1 的活性及其与其他抗逆转录病毒药物的协同作用。
AIDS. 2010 Nov 27;24(18):2789-96. doi: 10.1097/QAD.0b013e3283405c33.
引用本文的文献
1
The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis.延伸因子Tu（EF-Tu）在微生物致病机制中的多种功能作用
Front Microbiol. 2019 Oct 24;10:2351. doi: 10.3389/fmicb.2019.02351. eCollection 2019.
2
The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders.靶向物质P/神经激肽-1受体相互作用在炎症性中枢神经系统疾病中的治疗潜力
Front Cell Neurosci. 2017 Jan 4;10:296. doi: 10.3389/fncel.2016.00296. eCollection 2016.
3
Substance P and Antagonists of the Neurokinin-1 Receptor in Neuroinflammation Associated with Infectious and Neurodegenerative Diseases of the Central Nervous System.P物质与神经激肽-1受体拮抗剂在中枢神经系统感染性和神经退行性疾病相关神经炎症中的作用
J Neurol Neuromedicine. 2016;1(2):29-36. doi: 10.29245/2572.942x/2016/2.1020.
4
Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology.在 HIV 相关神经病变患者的大脑中，P 物质、神经激肽-1 受体和免疫标志物的表达。
J Neurol Sci. 2013 Nov 15;334(1-2):18-23. doi: 10.1016/j.jns.2013.07.008. Epub 2013 Aug 2.
本文引用的文献
1
HIV-1 alters neural and glial progenitor cell dynamics in the central nervous system: coordinated response to opiates during maturation.HIV-1 改变中枢神经系统中的神经和神经胶质前体细胞动态：成熟过程中对阿片类药物的协调反应。
Glia. 2012 Dec;60(12):1871-87. doi: 10.1002/glia.22403. Epub 2012 Aug 2.
2
Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.潜伏的 HIV-1 感染发生在多个造血祖细胞亚群中，并可通过 NF-κB 激活来逆转。
J Virol. 2012 Sep;86(17):9337-50. doi: 10.1128/JVI.00895-12. Epub 2012 Jun 20.
3
Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects.物质 P 介导热激信号在小鼠和人类缺血模型中祖细胞激活和血管生成中的作用。
Circulation. 2012 Apr 10;125(14):1774-86, S1-19. doi: 10.1161/CIRCULATIONAHA.111.089763. Epub 2012 Mar 5.
4
Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner.P 物质通过依赖于 p21 激活激酶的方式诱导 U373MG 细胞发生快速和短暂的质膜泡状化。
PLoS One. 2011;6(9):e25332. doi: 10.1371/journal.pone.0025332. Epub 2011 Sep 23.
5
A randomized, placebo controlled, double masked phase IB study evaluating the safety and antiviral activity of aprepitant, a neurokinin-1 receptor antagonist in HIV-1 infected adults.一项随机、安慰剂对照、双盲 Ib 期研究，评估神经激肽-1 受体拮抗剂阿瑞匹坦在 HIV-1 感染成人中的安全性和抗病毒活性。
PLoS One. 2011;6(9):e24180. doi: 10.1371/journal.pone.0024180. Epub 2011 Sep 8.
6
Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.神经激肽-1 受体：在免疫系统中的功能意义，涉及选定的感染和炎症。
Ann N Y Acad Sci. 2011 Jan;1217:83-95. doi: 10.1111/j.1749-6632.2010.05826.x. Epub 2010 Nov 22.
7
Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals.神经激肽-1 受体拮抗剂阿瑞匹坦抗 HIV-1 的活性及其与其他抗逆转录病毒药物的协同作用。
AIDS. 2010 Nov 27;24(18):2789-96. doi: 10.1097/QAD.0b013e3283405c33.
8
Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: implications for substance P in NK1-R immune cell trafficking into the CNS.神经激肽-1 受体（NK1-R）在 SIV 感染恒河猴大脑中的表达：神经激肽-1 受体免疫细胞向中枢神经系统迁移中 P 物质的意义。
Am J Pathol. 2010 Sep;177(3):1286-97. doi: 10.2353/ajpath.2010.091109. Epub 2010 Jul 29.
9
Neurokinin 1 receptor isoforms and the control of innate immunity.神经激肽1受体亚型与先天免疫的调控
Trends Immunol. 2009 Jun;30(6):271-6. doi: 10.1016/j.it.2009.03.006. Epub 2009 May 7.
10
The impact of perinatal HIV infection on older school-aged children's and adolescents' receptive language and word recognition skills.围产期HIV感染对大龄学龄儿童及青少年接受性语言和单词识别技能的影响。
AIDS Patient Care STDS. 2009 Jun;23(6):415-21. doi: 10.1089/apc.2008.0197.
Zotero 插件