Department of Applied Biological Chemistry, the University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Molecules. 2013 Jun 13;18(6):6952-68. doi: 10.3390/molecules18066952.
Allosamidins, which are secondary metabolites of the Streptomyces species, have chitin-mimic pseudotrisaccharide structures. They bind to catalytic centers of all family 18 chitinases and inhibit their enzymatic activity. Allosamidins have been used as chitinase inhibitors to investigate the physiological roles of chitinases in a variety of organisms. Two prominent biological activities of allosamidins were discovered, where one has anti-asthmatic activity in mammals, while the other has the chitinase-production- promoting activity in allosamidin-producing Streptomyces. In this article, recent studies on the novel biological activities of allosamidins are reviewed.
阿洛酰胺是链霉菌属的次生代谢产物，具有几丁质模拟的假三糖结构。它们结合到所有家族 18 几丁质酶的催化中心，抑制其酶活性。阿洛酰胺已被用作几丁质酶抑制剂，以研究几丁质酶在各种生物体中的生理作用。发现了阿洛酰胺的两个突出的生物学活性，其中一个在哺乳动物中具有抗哮喘活性，而另一个在产生阿洛酰胺的链霉菌中具有促进几丁质酶产生的活性。本文综述了阿洛酰胺的新型生物学活性的最新研究进展。
