用电化学方法在高氯酸锂-硝基甲烷体系中合成氮杂核苷衍生物。
Electrochemical synthesis of azanucleoside derivatives using a lithium perchlorate-nitromethane system.
机构信息
Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
出版信息
Chem Commun (Camb). 2013 Jul 25;49(58):6525-7. doi: 10.1039/c3cc43273d. Epub 2013 Jun 13.
PMID:23765333
Abstract
We have developed a highly efficient synthetic method for azanucleosides using a lithium perchlorate-nitromethane reaction medium, allowing direct and exclusive installation of various nucleophiles, including protected nucleobases into prolinol derivatives at the preferred 5-position.
摘要
我们开发了一种使用高氯酸锂-硝基甲烷反应介质的高效合成氮杂核苷的方法，允许直接且专一地将各种亲核试剂（包括保护的碱基）安装到脯氨醇衍生物的首选 5-位上。
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