加纳女性乳腺癌：有何变化？

Breast cancer in Ghanaian women: what has changed?

机构信息

Dept of Pathology, University of Ghana Medical School, PO Box 77, Korle-Bu, Accra, Ghana.

出版信息

Am J Clin Pathol. 2013 Jul;140(1):97-102. doi: 10.1309/AJCPW7TZLS3BFFIU.

DOI:10.1309/AJCPW7TZLS3BFFIU

PMID:23765539

Abstract

OBJECTIVES

To evaluate breast cancer in Ghanaian women and to compare these findings with those of previous studies by using histopathologic data.

METHODS

A review of all breast cancer specimens from January 2005 through December 2009 in our institution was conducted.

RESULTS

Of 4,109 female breast specimens reviewed, 1,342 (32.7%) were malignant. Mean (SD) patient age was 50.3 (13.3) years, and mean size of the primary tumors was 4.5 cm. Eighteen (1.3%) specimens were malignant phyllodes tumors. Significant positive associations were found between size of the primary tumor and histologic type (P = .01), histologic grade (P = .001), nodal involvement (P < .001), and TNM stage (P < .001).

CONCLUSIONS

More than 3 decades after the first publication of breast cancer in Ghanaian women, patients are still presenting with large clinically and histologically advanced invasive cancers.

摘要

目的

利用组织病理学数据评估加纳女性的乳腺癌情况，并与既往研究结果进行比较。

方法

对我院 2005 年 1 月至 2009 年 12 月期间所有乳腺癌标本进行了回顾性研究。

结果

在 4109 例女性乳腺标本中，1342 例（32.7%）为恶性肿瘤。患者的平均（标准差）年龄为 50.3（13.3）岁，原发肿瘤的平均大小为 4.5cm。18 例（1.3%）标本为恶性叶状肿瘤。原发肿瘤的大小与组织学类型（P=0.01）、组织学分级（P=0.001）、淋巴结受累（P<0.001）和 TNM 分期（P<0.001）显著相关。