West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, 58835University of Ghana, Legon 00233, Accra, Ghana.
Department of Medical Laboratory Sciences, School of Biochemical and Allied Health Sciences, 58835University of Ghana, Korle Bu 00233, Accra, Ghana.
Exp Biol Med (Maywood). 2020 Dec;245(18):1648-1655. doi: 10.1177/1535370220940992. Epub 2020 Jul 8.
Comorbidities impact negatively on breast cancer prognosis, especially in developing countries where cases are usually presented to clinics at advanced stages. This study aimed to determine the atherogenic index of plasma (AIP) and cardiovascular risk factors among Ghanaian women diagnosed with breast cancer. A total of 52 breast cancer patients were age-matched with 52 healthy controls. Sociodemographics of participants were obtained using a well-structured questionnaire. Pathological data of patients were obtained from medical records, and all clinical and anthropometric measurements were done using standard instruments. Lipid profile was determined from serum using enzymatic assays, and cardiovascular risk factors were calculated from estimated lipid parameters. Blood pressure, AIP, total cholesterol (T. chol), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) were significantly elevated ( < 0.05) in the breast cancer patients compared to the controls, but the reverse was observed for high-density lipoprotein cholesterol (HDL-c) ( < 0.01). Obesity (odds ratio [OR] = 2.51, = 0.015), hypertension (OR = 4.04, < 0.001), AIP (OR = 10.44, < 0.001), and dyslipidemia ( < 0.01) were significantly associated with breast cancer. AIP correlated positively with age (r = 0.244, < 0.05), body mass index (r = 0.225, < 0.05), blood pressure ( < 0.01), T. chol (r =0.418, < 0.01), and TG (r = 0.880, < 0.01), but inversely correlated with HDL-c (r = -0.460, < 0.01). A greater proportion (88%) of the patients presented with advanced breast cancer. AIP and cardiovascular risk factors were high in the breast cancer patients. Considering that AIP and cardiovascular disease risk factors are of interest in breast cancer patients, further studies are needed to understand the effect of AIP and cardiovascular risk factors on breast cancer outcomes.
合并症对乳腺癌的预后有负面影响，尤其是在发展中国家，这些国家的病例通常在晚期才被送到诊所。本研究旨在确定加纳确诊乳腺癌女性的血浆致动脉粥样硬化指数 (AIP) 和心血管危险因素。共招募了 52 名乳腺癌患者，并与 52 名健康对照者进行年龄匹配。使用结构良好的问卷获取参与者的社会人口统计学数据。从病历中获取患者的病理数据，使用标准仪器进行所有临床和人体测量学测量。使用酶法测定血清中的脂质谱，并从估算的脂质参数中计算心血管危险因素。与对照组相比，乳腺癌患者的血压、AIP、总胆固醇 (T. chol)、甘油三酯 (TG) 和低密度脂蛋白胆固醇 (LDL-c) 显著升高 ( < 0.05)，但高密度脂蛋白胆固醇 (HDL-c) 则相反 ( < 0.01)。肥胖症 (比值比 [OR] = 2.51， = 0.015)、高血压 (OR = 4.04， < 0.001)、AIP (OR = 10.44， < 0.001) 和血脂异常 ( < 0.01) 与乳腺癌显著相关。AIP 与年龄 (r = 0.244， < 0.05)、体重指数 (r = 0.225， < 0.05)、血压 ( < 0.01)、T. chol (r =0.418， < 0.01) 和 TG (r = 0.880， < 0.01) 呈正相关，但与 HDL-c 呈负相关 (r = -0.460， < 0.01)。患者中有 88% 的人呈现出晚期乳腺癌。乳腺癌患者的 AIP 和心血管危险因素较高。鉴于 AIP 和心血管疾病危险因素是乳腺癌患者关注的重点，需要进一步研究以了解 AIP 和心血管危险因素对乳腺癌结局的影响。
