Department of Medical Microbiology, Tropical Infectious Diseases Research and Education Centre, University Malaya, Kuala Lumpur, Malaysia.
J Med Virol. 2013 Aug;85(8):1420-5. doi: 10.1002/jmv.23622.
Relatively little is known about the burden of influenza in tropical countries. The seroprevalence of pandemic influenza A (H1N1) 2009, seasonal H1N1 and H3N2 was determined in Kuala Lumpur, Malaysia. Pre- and post-pandemic residual laboratory sera were tested by hemagglutination-inhibition. The seroprevalence of A(H1N1)pdm09 increased from 3.7% pre-pandemic to 21.9% post-pandemic, giving an overall cumulative incidence of 18.1% (95% CI, 13.8-22.5%), mainly due to increases in those <5, 5-17, and 18-29 years old. In contrast with findings from USA, Europe, and Australia, pre-existing seroprevalence to A(H1N1)pdm09 was low at 5.6% in the elderly age group of >55 years. A(H1N1)pdm09 affected almost a third of those <30 years in Kuala Lumpur. Pre-pandemic seroprevalence was 14.7% for seasonal H1N1 and 21.0% for H3N2, and these rates did not change significantly after the pandemic. Seasonal and pandemic influenza cause a considerable burden in tropical Malaysia, particularly in children and young adults.
关于流感在热带国家的负担，人们知之甚少。在马来西亚吉隆坡，确定了大流行性流感 A(H1N1)2009、季节性 H1N1 和 H3N2 的血清流行率。通过血凝抑制试验检测了大流行前和大流行后的残留实验室血清。A(H1N1)pdm09 的血清流行率从大流行前的 3.7%上升到大流行后的 21.9%，总累积发病率为 18.1%（95%CI，13.8-22.5%），主要是由于<5 岁、5-17 岁和 18-29 岁的人群发病率增加。与美国、欧洲和澳大利亚的发现不同，>55 岁的老年人群中，A(H1N1)pdm09 的预先存在血清流行率较低，为 5.6%。A(H1N1)pdm09 几乎影响了吉隆坡三分之一的<30 岁人群。季节性 H1N1 的大流行前血清流行率为 14.7%，H3N2 为 21.0%，大流行后这些比率没有显著变化。季节性流感和大流行性流感在马来西亚热带地区造成了相当大的负担，特别是在儿童和青年中。
