Department for Interventions in Health-Care Facilities, Hellenic Center for Diseases, Control and Prevention, 3-5 Agrafon Street, Athens 15123, Greece.
Vaccine. 2011 Sep 2;29(38):6664-9. doi: 10.1016/j.vaccine.2011.06.098. Epub 2011 Jul 14.
Knowledge of seroprevalence rates against 2009 pandemic H1N1 virus will assist vaccination recommendations and the preparation of the health-care system during subsequent years. This study was conducted in Greece during June-August 2010 to estimate the seroprevalence rate against pandemic H1N1 virus. Persons presenting in 29 health-care facilities across the country were studied. Seroprevalence was estimated employing a virus-free ELISA that specifically recognizes 2009 H1N1 virus antibodies in human sera. Sera collected from 2005 to April 2009 were also used to estimate pre-pandemic seroprevalence rates. A total of 954 persons were studied. The overall seroprevalence rate was 28.5% (95% confidence interval=25.6-31.3%). Age-specific rates were 34.2% in persons 0-4 years, 36.3% in persons 5-19 years, 25.0% in persons 20-39 years, 23.4% in persons 40-59 years, and 31.8% in persons ≥ 60 years. The highest rates were recorded in the Regions of Ionian Islands (67%) and Epirus (42.9%), while the lowest (8.4%) in the Region of Thessaly. Age-specific attack rates of infection during 2009-2010 were 28.8% in persons 0-4 years, 32.5% in persons 5-19 years, 14.3% in persons 20-39 years, 19.1% in persons 40-59 years, and 14.4% in persons ≥ 60 years. Multivariate analysis revealed that Region of residence and caring for children <5 years were associated with increased risk for seropositivity. Urbanity, personal and family characteristics, working in a health-care facility or in a school, history of pandemic H1N1 vaccination or history of influenza-like illness during 2009-2010 were not associated with increased risk for seropositivity.
了解针对 2009 年大流行 H1N1 病毒的血清流行率有助于为随后几年的疫苗接种建议和医疗保健系统的准备提供信息。本研究于 2010 年 6 月至 8 月在希腊进行，旨在估计针对大流行 H1N1 病毒的血清流行率。在全国 29 家医疗机构就诊的人员参与了研究。使用一种专门识别人类血清中 2009 年 H1N1 病毒抗体的无病毒 ELISA 来估计血清流行率。还使用了 2005 年至 2009 年 4 月收集的血清来估计大流行前的血清流行率。共有 954 人参与了研究。总体血清流行率为 28.5%（95%置信区间为 25.6-31.3%）。按年龄划分的流行率分别为 0-4 岁人群为 34.2%，5-19 岁人群为 36.3%，20-39 岁人群为 25.0%，40-59 岁人群为 23.4%，≥60 岁人群为 31.8%。在爱奥尼亚群岛（67%）和伊庇鲁斯（42.9%）地区记录到的流行率最高，而在塞萨利（Thessaly）地区记录到的流行率最低（8.4%）。2009-2010 年期间，0-4 岁人群的感染年龄特异性发病率为 28.8%，5-19 岁人群为 32.5%，20-39 岁人群为 14.3%，40-59 岁人群为 19.1%，≥60 岁人群为 14.4%。多变量分析显示，居住地和照顾 5 岁以下儿童与血清阳性风险增加有关。城市环境、个人和家庭特征、在医疗机构或学校工作、2009-2010 年期间接种大流行 H1N1 疫苗或流感样疾病史与血清阳性风险增加无关。
