循环 CD4+阳性淋巴细胞水平作为晚期喉癌患者诱导化疗反应的预测指标。
Circulating CD4-positive lymphocyte levels as predictor of response to induction chemotherapy in patients with advanced laryngeal cancer.
机构信息
The Department of Otolaryngology-Head and Neck Surgery, University of Michigan Schools of Medicine and Public Health, Ann Arbor, Michigan.
出版信息
Head Neck. 2014 Jan;36(1):9-14. doi: 10.1002/hed.23263. Epub 2013 Jun 14.
Abstract
BACKGROUND
Tumor regression after induction chemotherapy (ICT) identifies laryngeal cancers that are responsive to chemoradiation. Patient immune parameters have recently been associated with response to chemotherapy and may identify responding patients. A retrospective analysis was performed to determine if pretreatment, circulating T lymphocyte levels predicted ICT response in patients with advanced laryngeal cancer.
METHODS
Pretreatment, circulating T lymphocyte subpopulations were correlated with response to therapy and survival. Results were compared with similar data from an identical phase II trial involving patients with oropharyngeal cancer.
RESULTS
An increased percentage of CD4+ cells predicted response to ICT and suggested improved survival in patients with laryngeal, but not oropharyngeal, cancer. In the combined group of patients, increased CD4 levels predicted response to ICT.
CONCLUSION
These findings demonstrate the potential importance of the immune system in chemotherapy response and clinical outcome. Differences in findings between patients with advanced laryngeal and oropharyngeal cancer may reflect different cellular immunity function in the patients with human papillomavirus (HPV)-16+ oropharyngeal cancer.
摘要
背景
诱导化疗（ICT）后的肿瘤消退可识别出对放化疗有反应的喉癌。患者的免疫参数最近与化疗反应相关，并可能识别出有反应的患者。进行了一项回顾性分析，以确定在晚期喉癌患者中，治疗前的循环 T 淋巴细胞水平是否可预测 ICT 反应。
方法
将治疗前的循环 T 淋巴细胞亚群与治疗反应和生存相关联。结果与涉及口咽癌患者的相同二期试验的类似数据进行了比较。
结果
CD4+细胞的百分比增加预示着 ICT 反应和改善了喉癌患者的生存，但口咽癌患者则不然。在联合患者组中，CD4 水平的增加预示着 ICT 的反应。
结论
这些发现表明免疫系统在化疗反应和临床结果中的重要性。晚期喉癌和口咽癌患者之间的发现差异可能反映了 HPV-16+口咽癌患者的细胞免疫功能不同。
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