Singh Sareena, Himler Justin, Nagel Christa I, Resnick Kimberly
Division of Gynecologic Oncology, MetroHealth Medical Center, Cleveland, OH, USA.
Department of Obstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH, USA.
Obstet Gynecol Int. 2017;2017:8584605. doi: 10.1155/2017/8584605. Epub 2017 Jan 23.
. To determine the prognostic significance of pretreatment levels of circulating lymphocyte (CLC), neutrophil (CNC), and monocyte (CMC) counts in patients with locally advanced cervical carcinoma (CC) treated with definitive radiation. . A retrospective, dual-institution review of patients with Stage IB2-IVA CC from 2005 to 2015. Progression-free (PFS) and Overall Survival (OS) were determined for high and low CLC, CNC, and CMC groups. Multivariate analysis was used to confirm prognostic value of baseline leukocyte counts. . 181 patients were included. Median follow-up time was 26 (3-89) months. CNC had no effect on PFS or OS. PFS was similar between CMC groups; however, OS was significantly improved for patients with low CMC (62.5 versus 45.3 months, = 0.016). High CLC was associated with improved PFS (48.5 versus 27.8 months, = 0.048) and OS (58.4 versus 34.9 months, = 0.048). On multivariate analysis, high CNC was associated with increased relapse risk (HR 1.12, = 0.006) and low CLC was associated with increased mortality risk (HR 0.67, = 0.027). . This study demonstrates that leukocyte values can provide prognostic information in CC. These hypothesis-generating findings warrant further prospective investigations.
确定接受根治性放疗的局部晚期宫颈癌（CC）患者治疗前循环淋巴细胞（CLC）、中性粒细胞（CNC）和单核细胞（CMC）计数水平的预后意义。
对2005年至2015年IB2-IVA期CC患者进行回顾性、双机构研究。确定高、低CLC、CNC和CMC组的无进展生存期（PFS）和总生存期（OS）。采用多变量分析来确认基线白细胞计数的预后价值。
纳入181例患者。中位随访时间为26（3-89）个月。CNC对PFS或OS无影响。CMC组之间的PFS相似；然而，低CMC患者的OS显著改善（62.5个月对45.3个月，P=0.016）。高CLC与改善的PFS（48.5个月对27.8个月，P=0.048）和OS（58.4个月对34.9个月，P=0.048）相关。多变量分析显示，高CNC与复发风险增加相关（风险比1.12，P=0.006），低CLC与死亡风险增加相关（风险比0.67，P=0.027）。
本研究表明，白细胞值可为CC提供预后信息。这些产生假设的发现值得进一步进行前瞻性研究。
