对映选择性氟胺化：使用阴离子相转移催化的共轭二烯 1,4-加成反应。
Enantioselective fluoroamination: 1,4-addition to conjugated dienes using anionic phase-transfer catalysis.
机构信息
Department of Chemistry, University of California-Berkeley, Latimer Hall, Berkeley, CA, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7724-7. doi: 10.1002/anie.201302002. Epub 2013 Jun 13.
PMID:23766145
Abstract
Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.
摘要
手性阴离子相转移催化（PTC）已被应用于 1,3-二烯的对映选择性氟环化反应。该方法以高产率和高达 96%的对映选择性得到了前所未有的氟代苯并[f]异喹啉和八氢异喹啉产物。新型氟代胺试剂在所需转化中优于 Selectfluor。
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