Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, China.
Org Lett. 2011 Mar 4;13(5):1122-5. doi: 10.1021/ol103152t. Epub 2011 Feb 10.
A series of α,β-divinyl tetrahydropyrroles, synthesized by asymmetric allylic C-H bond activation/conjugated diene addition reaction of ene-2-dienes, were found to be very efficient chiral chain diene ligands in the rhodium-catalyzed conjugated addition of organoboronic acids to various α,β-unsaturated compounds, achieving the desired chiral adducts with good to excellent yields and ee values.
一系列 α,β-二乙烯基四氢吡咯，通过烯-2-二烯的不对称烯丙基 C-H 键活化/共轭二烯加成反应合成，被发现是非常有效的手性链二烯配体，在铑催化的有机硼酸对各种 α,β-不饱和化合物的共轭加成反应中，以良好到优异的收率和 ee 值实现了所需的手性加成产物。
