Department of Psychology, Yale University, New Haven, Connecticut 06520, USA.
Yale J Biol Med. 2013 Jun 13;86(2):117-25. Print 2013 Jun.
Chronic stress plays a role in the etiology of several affective and anxiety-related disorders. Despite this, its mechanistic effects on the brain are still unclear. Of particular interest is the effect of chronic stress on the amygdala, which plays a key role in the regulation of emotional responses and memory consolidation. This review proposes a neuroplasticity model for the effects of chronic stress in this region, emphasizing the roles of glutamate and BDNF signaling. This model provides a review of recent discoveries of the effects of chronic stress in the amygdala and reveals pathways for future research.
慢性应激在几种情感和焦虑相关障碍的发病机制中起作用。尽管如此，其对大脑的机械影响仍不清楚。特别感兴趣的是慢性应激对杏仁核的影响，杏仁核在调节情绪反应和记忆巩固中起着关键作用。本综述提出了慢性应激对该区域影响的神经可塑性模型，强调了谷氨酸和 BDNF 信号的作用。该模型回顾了慢性应激对杏仁核影响的最新发现，并揭示了未来研究的途径。
