University of Alabama School of Medicine, Birmingham, Alabama, USA.
Yale J Biol Med. 2013 Jun 13;86(2):147-56. Print 2013 Jun.
Information processing in individuals with autism is marked by a unique interplay of strengths and weaknesses that in concert distinguishes social cognition in autism from individuals with typical-functioning brains. In autism, difficulties with higher cognitive processing and enhancement of low-level visuospatial processing, such as in visual search tasks, may lead to diminished central coherence, which has the potential to hinder how an individual functions in social interactions where integration of components such as intention, emotion, and context paints the global picture necessary for social processing. A more thorough understanding of the cognitive and neural processes in autism is important for the advancement of intervention programs. The intention of this review is to discuss the implications of neuroimaging and behavioral studies that have analyzed the higher cognitive functions in individuals with high-functioning autism, with a particular emphasis on studies that have investigated visuospatial processing.
个体自闭症的信息处理受到独特的优势和劣势的共同影响,这种共同作用将自闭症的社会认知与具有典型功能的大脑个体区分开来。在自闭症中,较高认知处理的困难和较低水平的视觉空间处理的增强,例如在视觉搜索任务中,可能导致中央连贯性的降低,这有可能阻碍个体在社交互动中的功能,在社交处理中,意图、情感和上下文等组件的整合描绘了必要的全局图景。更深入地了解自闭症中的认知和神经过程对于干预计划的推进很重要。本综述的目的是讨论分析高功能自闭症个体的较高认知功能的神经影像学和行为研究的意义,特别强调研究视觉空间处理的研究。