细胞色素P450与帕金森病。苯妥英的对羟基化作用不佳。
Cytochrome P450 and Parkinson's disease. Poor parahydroxylation of phenytoin.
作者信息
Ferrari M D, Peeters E A, Haan J, Roos R A, Vermey P, de Wolff F A, Buruma O J
机构信息
Department of Neurology, University Hospital of Leiden, The Netherlands.
出版信息
J Neurol Sci. 1990 May;96(2-3):153-7. doi: 10.1016/0022-510x(90)90128-a.
PMID:2376747
Abstract
Phenytoin-parahydroxylation capacity was determined in 24 patients with Parkinson's disease (PD) and 17 controls. Different function of the phenytoin-metabolizing cytochrome P450 subsystem was found in 6 patients, but in none of the controls. These results add to previous studies suggesting a relation between the pathogenesis of PD and the function of cytochrome P450 subsystems.
摘要
在24例帕金森病（PD）患者和17名对照者中测定了苯妥英对羟基化能力。在6例患者中发现了苯妥英代谢细胞色素P450亚系统的不同功能，但对照者中均未发现。这些结果补充了先前的研究，提示PD的发病机制与细胞色素P450亚系统的功能之间存在关联。
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