Takamatsu Atsuko, Ishikawa Takuji, Shinohara Kyosuke, Hamada Hiroshi
Department of Electrical Engineering and Bioscience, Waseda University, Tokyo 169-8555, Japan.
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 May;87(5):050701. doi: 10.1103/PhysRevE.87.050701. Epub 2013 May 15.
Rotational movement of isolated single cilia in mice embryo was investigated, which generates leftward fluid flow in the node cavity and plays an important role in left-right determination. The leftward unidirectional flow results from tilting of the rotational axis of the cilium to the posterior side. By combining computational fluid dynamics with experimental observations, we demonstrate that the leftward stroke can be more effective than expected for cases in which cilia tilting alone is considered with the no-slip condition under constant driving torque. Our results suggest that the driving torque is asymmetric.
研究了小鼠胚胎中分离出的单个纤毛的旋转运动，其在节点腔中产生向左的流体流动，在左右决定中起重要作用。向左的单向流动是由于纤毛的旋转轴向后倾斜所致。通过将计算流体动力学与实验观察相结合，我们证明，在恒定驱动扭矩下的无滑移条件下，仅考虑纤毛倾斜的情况下，向左的摆动可能比预期更有效。我们的结果表明驱动扭矩是不对称的。
