Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Curr Eye Res. 2013 Sep;38(9):903-9. doi: 10.3109/02713683.2013.800888.
The lamina cribrosa (LC) is a sieve-like structure in the sclera where retinal ganglion cell axons exit from the eye. The LC has been known to play a critical role in the pathogenesis of glaucoma. With the advent of imaging technologies, such as enhanced depth imaging, spectral-domain optical coherence tomography (OCT) enables us to unveil the LC in vivo features. The application of adaptive optics technology and a compensatory image-processing algorithm has further improved the visualization of the beams and pores and neural pathways of the LC and the scleral insertion sites. Monitoring the changes of these structures in relation to acute and chronic elevation of intraocular pressure would be germane to decipher the relationship between the stress and strain response of the LC and optic nerve damage and improve our understanding of glaucoma pathophysiology. While the impact of investigating the integrity of LC is substantive, considerable challenges remain for imaging the LC. Nevertheless, with the rapid development of the OCT technology, it is expected that some of these limitations can be overcome and the potentials of LC imaging will be unraveled.
筛板（LC）是巩膜中的一种筛状结构，视网膜神经节细胞轴突由此离开眼球。LC 在青光眼的发病机制中起着关键作用。随着成像技术的出现，如增强深度成像，频域光相干断层扫描（OCT）使我们能够揭示 LC 的活体特征。自适应光学技术和补偿图像处理算法的应用进一步提高了 LC 的光束和孔隙以及神经通路和巩膜插入部位的可视化程度。监测这些结构在急性和慢性眼内压升高时的变化，与 LC 的应力和应变反应与视神经损伤之间的关系有关，有助于提高我们对青光眼病理生理学的认识。虽然研究 LC 的完整性具有重要意义，但对 LC 进行成像仍面临着相当大的挑战。然而，随着 OCT 技术的快速发展，预计可以克服其中的一些局限性，揭示 LC 成像的潜力。
