Zhao Ling, Zhang Qingyuan, Luan Xin, Huang Xu, Zhao Shu, Zhao Hong
Department of Medical Oncology, The Tumor Hospital of Harbin Medical University Harbin 150040, China.
Int J Clin Exp Pathol. 2015 Feb 1;8(2):2033-8. eCollection 2015.
We conducted a case-control study in a Chinese population, and investigated the role of STAT3 rs4796793 and STAT5b rs6503691 polymorphisms in the risk and clinical outcome of breast cancer. STAT5b rs6503691 polymorphisms and STAT3 rs4796793 polymorphisms were genotyped by TaqMan SNP Genotyping Assays on the ABI 7500 fast real-time PCR platform. Unconditional logistic regression analyses showed that subjects carrying the GG genotype of STAT3 rs4796793 had a significantly increased risk of breast cancer, with an adjusted OR (95% CI) of 0.35 (0.12-0.95). In the Cox proportional hazards model, we observed that individuals carrying CG+GG genotype of STAT3 rs4796793 was associated with reduced risk of death from breast cancer when compared with CC genotype (HR = 0.43, 95% CI = 0.20-0.93). Our study found that STAT3 rs4796793 polymorphism plays an important role in influence the development and overall survival of breast cancer patients.
我们在中国人群中开展了一项病例对照研究，调查信号转导和转录激活因子3（STAT3）rs4796793及信号转导和转录激活因子5b（STAT5b）rs6503691基因多态性在乳腺癌风险及临床结局中的作用。采用TaqMan SNP基因分型检测法在ABI 7500快速实时聚合酶链反应（PCR）平台上对STAT5b rs6503691基因多态性和STAT3 rs4796793基因多态性进行基因分型。非条件逻辑回归分析显示，携带STAT3 rs4796793基因GG基因型的受试者患乳腺癌风险显著增加，校正比值比（OR）（95%置信区间）为0.35（0.12 - 0.95）。在Cox比例风险模型中，我们观察到，与CC基因型相比，携带STAT3 rs4796793基因CG + GG基因型的个体乳腺癌死亡风险降低（风险比 = 0.43，95%置信区间 = 0.20 - 0.93）。我们的研究发现，STAT3 rs4796793基因多态性在影响乳腺癌患者的疾病发展及总生存方面发挥重要作用。
