Ikezaki N, Nakano T, Kiyama S, Matsumoto Y, Kukita H, Tomita M, Nishimura Y, Nakayama M, Sato T
Third Department of Internal Medicine, Kumamoto Medical School.
Nihon Jinzo Gakkai Shi. 1990 Apr;32(4):435-9.
A 54 year-old woman who had had 4 years history of ulcerative colitis (UC) was admitted to our hospital because of recently developed proteinuria and leg edema. On admission, laboratory findings disclosed massive proteinuria, hypoalbuminemia, acceleration of ESR and elevated of CRP. Her abdominal symptom was remitted. Renal biopsy showed amyloid deposition in glomeruli and arteriole. Amyloid deposition was also found on rectal biopsy. She had no evidence of familial amyloidosis and multiple myeloma. In this case, amyloid deposition might be developed after UC. Secondary amyloidosis due to UC was extremely rare, only 3 cases including ours were reported in Japan.
一名患有溃疡性结肠炎（UC）4年的54岁女性因近期出现蛋白尿和腿部水肿入院。入院时，实验室检查发现大量蛋白尿、低白蛋白血症、血沉加快和CRP升高。她的腹部症状已缓解。肾活检显示肾小球和小动脉有淀粉样沉积。直肠活检也发现了淀粉样沉积。她没有家族性淀粉样变性和多发性骨髓瘤的证据。在这种情况下，淀粉样沉积可能在UC后发生。UC所致的继发性淀粉样变性极为罕见，在日本仅报道了包括我们这例在内的3例。
