Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, Program in Global Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Curr Opin Virol. 2013 Jun;3(3):238-44. doi: 10.1016/j.coviro.2013.05.012. Epub 2013 Jun 13.
Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of several human malignancies. The virus is able to modulate pro-proliferative pathways to its advantage, while simultaneously inhibiting pro-apoptotic signaling pathways. These functions are carried out by multiple viral proteins acting in concert. The overall outcome is the survival and proliferation of the infected cell. Additionally, the virus also modulates innate immune pathways to allow for prolonged survival of the infected cell following primary infection, and during viral latency. Here we review the latest advances in our knowledge of KSHV pathogenesis.
卡波西肉瘤相关疱疹病毒（KSHV）是几种人类恶性肿瘤的病原体。该病毒能够调节促有丝分裂途径，使其受益，同时抑制促凋亡信号通路。这些功能是由多个协同作用的病毒蛋白执行的。其最终结果是感染细胞的存活和增殖。此外，该病毒还调节先天免疫途径，以允许感染细胞在初次感染后和病毒潜伏期内长期存活。在这里，我们综述了我们对 KSHV 发病机制的最新认识。
